Entity Details

Primary name FGD3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5JSP0
EntryNameFGD3_HUMAN
FullNameFYVE, RhoGEF and PH domain-containing protein 3
TaxID9606
Evidenceevidence at protein level
Length725
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesFGD3

GO terms

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GOName
GO:0001726 ruffle
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0007010 cytoskeleton organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0031267 small GTPase binding
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0046847 filopodium assembly
GO:0046872 metal ion binding
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000306 FYVE zinc fingerDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR035941 FGD1-4, C-terminal PH domainDomainDomain

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
FGD3_HUMANCDC42_HUMANBioGRID18363964 32203420 details
FGD3_HUMANRHG22_HUMANBioGRID, IntAct32203420 details
FGD3_HUMANFBW1A_HUMANBioGRID18363964 details