Entity Details

Primary name TEN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6N022
EntryNameTEN4_HUMAN
FullNameTeneurin-4
TaxID9606
Evidenceevidence at protein level
Length2769
SequenceStatuscomplete
DateCreated2006-10-31
DateModified2021-06-02

Ontological Relatives

GenesTENM4

GO terms

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GOName
GO:0001702 gastrulation with mouth forming second
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007165 signal transduction
GO:0031641 regulation of myelination
GO:0031643 positive regulation of myelination
GO:0032289 central nervous system myelin formation
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0046982 protein heterodimerization activity
GO:0048666 neuron development
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050839 cell adhesion molecule binding
GO:0060038 cardiac muscle cell proliferation
GO:0060912 cardiac cell fate specification
GO:2000543 positive regulation of gastrulation

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR006530 YD repeatRepeatRepeat
IPR008969 Carboxypeptidase-like, regulatory domain superfamilyFamilyHomologous superfamily
IPR009471 Teneurin intracellular, N-terminalDomainDomain
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013111 EGF-like domain, extracellularDomainDomain
IPR022385 Rhs repeat-associated coreDomainDomain
IPR027691 Teneurin-3/4FamilyFamily
IPR028916 Tox-GHH domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616736 OMIMTremor, hereditary essential 5 (ETM5)A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Interactions

9 interactions