Entity Details

Primary name NEK10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6ZWH5
EntryNameNEK10_HUMAN
FullNameSerine/threonine-protein kinase Nek10
TaxID9606
Evidenceevidence at protein level
Length1172
SequenceStatuscomplete
DateCreated2006-11-28
DateModified2021-06-02

Ontological Relatives

GenesNEK10

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0006468 protein phosphorylation
GO:0031954 positive regulation of protein autophosphorylation
GO:0043406 positive regulation of MAP kinase activity
GO:0046872 metal ion binding
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120197 mucociliary clearance
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1902911 protein kinase complex

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR042666 Serine/threonine-protein kinase Nek10, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618781 OMIMCiliary dyskinesia, primary, 44 (CILD44)A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD44 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
NEK10_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
NEK10_HUMANM3K1_HUMANBioGRID25260751 details