Entity Details

Primary name AT11C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NB49
EntryNameAT11C_HUMAN
FullNamePhospholipid-transporting ATPase IG
TaxID9606
Evidenceevidence at protein level
Length1132
SequenceStatuscomplete
DateCreated2003-04-30
DateModified2021-06-02

Ontological Relatives

GenesATP11C

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002329 pre-B cell differentiation
GO:0005524 ATP binding
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031901 early endosome membrane
GO:0034220 ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0045579 positive regulation of B cell differentiation
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0090555 phosphatidylethanolamine flippase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome membrane
Endoplasmic reticulum membrane
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR006539 P-type ATPase, subfamily IVFamilyFamily
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR030363 Phospholipid-transporting ATPase IGFamilyFamily
IPR032630 P-type ATPase, C-terminalDomainDomain
IPR032631 P-type ATPase, N-terminalDomainDomain
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
301015 OMIMHemolytic anemia, congenital, X-linked (HAXL)An X-linked hematologic disease characterized by shortened survival of erythrocytes due to congenital hemolysis that cannot be compensated by bone marrow activity. Clinical features are mild jaundice and anemia. Red cells morphology is normal. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AT11C_HUMANCC50A_HUMANBioGRID, IntAct, UniProt21914794 31571211 details