Entity Details

Primary name TT21A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NDW8
EntryNameTT21A_HUMAN
FullNameTetratricopeptide repeat protein 21A
TaxID9606
Evidenceevidence at protein level
Length1320
SequenceStatuscomplete
DateCreated2007-06-26
DateModified2021-06-02

Ontological Relatives

GenesTTC21A

GO terms

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GOName
GO:0005929 cilium
GO:0007286 spermatid development
GO:0030317 flagellated sperm motility
GO:0030991 intraciliary transport particle A
GO:0035721 intraciliary retrograde transport
GO:0061512 protein localization to cilium

Subcellular Location

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Domains

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DomainNameCategoryType
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR040364 Tetratricopeptide repeat protein 21A/21BFamilyFamily

Diseases

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Disease IDSourceNameDescription
618429 OMIMSpermatogenic failure 37 (SPGF37)An autosomal recessive infertility disorder characterized by asthenoteratozoospermia. Spermatozoa exhibit multiple morphologic abnormalities, primarily consisting of short or absent flagella, and neck defects at the head-tail junction. The disease is caused by variants affecting the gene represented in this entry.