Entity Details

Primary name DVL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14640
EntryNameDVL1_HUMAN
FullNameSegment polarity protein dishevelled homolog DVL-1
TaxID9606
Evidenceevidence at protein level
Length695
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDVL1

GO terms

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GOName
GO:0001505 regulation of neurotransmitter levels
GO:0001934 positive regulation of protein phosphorylation
GO:0005109 frizzled binding
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006355 regulation of transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007269 neurotransmitter secretion
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0008013 beta-catenin binding
GO:0010976 positive regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0016328 lateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021915 neural tube development
GO:0022007 convergent extension involved in neural plate elongation
GO:0030136 clathrin-coated vesicle
GO:0030426 growth cone
GO:0031122 cytoplasmic microtubule organization
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0035176 social behavior
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0035567 non-canonical Wnt signaling pathway
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043113 receptor clustering
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048668 collateral sprouting
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
GO:0050808 synapse organization
GO:0050821 protein stabilization
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060134 prepulse inhibition
GO:0060997 dendritic spine morphogenesis
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0099054 presynapse assembly
GO:0150012 positive regulation of neuron projection arborization
GO:1903827 regulation of cellular protein localization
GO:1904886 beta-catenin destruction complex disassembly
GO:1905386 positive regulation of protein localization to presynapse
GO:1990909 Wnt signalosome
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR001158 DIX domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR003351 Dishevelled protein domainDomainDomain
IPR008339 Dishevelled familyFamilyFamily
IPR008340 Dishevelled-1FamilyFamily
IPR015506 Dishevelled-related proteinFamilyFamily
IPR024580 Dishevelled C-terminalDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616331 OMIMRobinow syndrome, autosomal dominant 2 (DRS2)A rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, hypoplastic external genitalia in males, costovertebral segmentation defects, and renal anomalies. The disease is caused by variants affecting the gene represented in this entry.

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
DVL1_HUMANUBP13_HUMANBioGRID, HPRD, IntAct16169070 details
DVL1_HUMANPSA3_HUMANBioGRID, IntAct21988832 details
DVL1_HUMANSIPA1_HUMANBioGRID, IntAct21988832 details
DVL1_HUMANANXA7_HUMANBioGRID, MINT21900206 details
DVL1_HUMANDAAM1_HUMANHPRD, MINT11779461 22705156 details
DVL1_HUMANLRRK2_HUMANBioGRID, IntAct19625296 details
DVL1_HUMANKC1E_HUMANBioGRID, HPRD, IntAct11425858 11487578 11818547 details
DVL1_HUMANDVL3_HUMANbhf-ucl, BioGRID, HPRD10330181 32296183 details
DVL1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
DVL1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
DVL1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
DVL1_HUMANMSH2_HUMANBioGRID, MINT24412244 details
DVL1_HUMANRB_HUMANBioGRID, MINT24412244 details
DVL1_HUMANSCYL2_HUMANbhf-ucl19643732 details
DVL1_HUMANEPS8_HUMANBioGRID, HPRD10581192 details
DVL1_HUMANHECW1_HUMANBioGRID, HPRD14684739 details
DVL1_HUMANDAB2_HUMANBioGRID12805222 details
DVL1_HUMANSMAD1_HUMANBioGRID12650946 details
DVL1_HUMANSMAD2_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANSMAD3_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANSMAD4_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANSMAD7_HUMANBioGRID, HPRD12650946 details
DVL1_HUMANAXIN1_HUMANBioGRID, HPRD10330403 10428961 12556519 18632848 9482734 details
DVL1_HUMANATN1_HUMANBioGRID10332026 details
DVL1_HUMANKC1D_HUMANBioGRID, HPRD11818547 details
DVL1_HUMANNEDD4_HUMANBioGRID22467858 details
DVL1_HUMANNCK2_HUMANBioGRID25416956 details
DVL1_HUMANTRI69_HUMANBioGRID25416956 details
DVL1_HUMANSMYD1_HUMANBioGRID32296183 details
DVL1_HUMANKLH12_HUMANBioGRID32296183 32574548 details
DVL1_HUMANBAG3_HUMANBioGRID32296183 details
DVL1_HUMANBRD7_HUMANHPRD12941796 details
DVL1_HUMANVANG1_HUMANHPRD15456783 details
DVL1_HUMANPPM1A_HUMANHPRD10644691 details
DVL1_HUMANDYLT1_HUMANHPRD10644691 details
DVL1_HUMANHDHD2_HUMANHPRD16169070 details
DVL1_HUMANDAPLE_HUMANHPRD14750955 details
DVL1_HUMANARHGJ_HUMANMINT18256687 details
DVL1_HUMANAPC_HUMANIntAct, MINT11425858 20224554 details
DVL1_HUMANDVL2_HUMANBioGRID, MINT20224554 24643799 26186194 28514442 31340145 details
DVL1_HUMANTFDP1_HUMANMINT22773187 details
DVL1_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct10806215 25241761 details
DVL1_HUMANCSK21_HUMANBioGRID, HPRD, IntAct10806215 25241761 details
DVL1_HUMANDVL1_HUMANbhf-ucl, BioGRID, HPRD10330181 details
DVL1_HUMANWWTR1_HUMANbhf-ucl, BioGRID20412773 details
DVL1_HUMANNKD2_HUMANbhf-ucl, BioGRID20177058 details
DVL1_HUMANSIR1_HUMANBioGRID, DIP20439735 details
DVL1_HUMANARRB1_HUMANBioGRID, HPRD11742073 details
DVL1_HUMANFRAT1_HUMANBioGRID, HPRD10428961 details
DVL1_HUMANCYLD_HUMANBioGRID20227366 details
DVL1_HUMANSDC4_HUMANBioGRID20639201 details
DVL1_HUMANITCH_HUMANBioGRID22826439 details
DVL1_HUMANHUWE1_HUMANBioGRID24643799 details
DVL1_HUMANNUMA1_HUMANBioGRID24469800 details
DVL1_HUMANSTAU1_HUMANBioGRID29395067 details
DVL1_HUMANVANG2_HUMANHPRD12490194 details
DVL1_HUMANRAC1_HUMANHPRD12533515 details