Entity Details

Primary name SORT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99523
EntryNameSORT_HUMAN
FullNameSortilin
TaxID9606
Evidenceevidence at protein level
Length831
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSORT1

GO terms

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GOName
GO:0001503 ossification
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006622 protein targeting to lysosome
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006895 Golgi to endosome transport
GO:0006897 endocytosis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007275 multicellular organism development
GO:0008333 endosome to lysosome transport
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010465 nerve growth factor receptor activity
GO:0010468 regulation of gene expression
GO:0014902 myotube differentiation
GO:0016021 integral component of membrane
GO:0016050 vesicle organization
GO:0019899 enzyme binding
GO:0030136 clathrin-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030379 neurotensin receptor activity, non-G protein-coupled
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
GO:0032509 endosome transport via multivesicular body sorting pathway
GO:0032580 Golgi cisterna membrane
GO:0032868 response to insulin
GO:0043025 neuronal cell body
GO:0045599 negative regulation of fat cell differentiation
GO:0046323 glucose import
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048227 plasma membrane to endosome transport
GO:0048406 nerve growth factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0090160 Golgi to lysosome transport
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1905394 retromer complex binding

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Endosome membrane
Golgi apparatus
Lysosome membrane
Nucleus membrane

Domains

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DomainNameCategoryType
IPR006581 VPS10DomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR031777 Sortilin, C-terminalDomainDomain
IPR031778 Sortilin, N-terminalDomainDomain

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
SORT_HUMANGGA2_HUMANBioGRID, HPRD, MINT11331584 11390366 11821067 details
SORT_HUMANGGA1_HUMANBioGRID, HPRD, I2D, MINT11390366 11821067 11859376 20015111 20676133 details
SORT_HUMANGRN_HUMANDIP, MINT23236149 24070898 details
SORT_HUMANAMRP_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct10085125 18687776 19122660 20584990 9013611 9927419 details
SORT_HUMANLIPL_HUMANbhf-ucl10085125 details
SORT_HUMANNGF_HUMANbhf-ucl, BioGRID, DIP, HPRD14985763 19122660 20159974 details
SORT_HUMANNEUT_HUMANbhf-ucl, BioGRID, HPRD, IntAct14985763 16087676 21261755 24128306 9756851 details
SORT_HUMANNTRK3_HUMANbhf-ucl, BioGRID21102451 details
SORT_HUMANNTRK1_HUMANbhf-ucl, BioGRID21102451 25921289 details
SORT_HUMANNTRK2_HUMANbhf-ucl, BioGRID21102451 details
SORT_HUMANFAM3C_HUMANIntAct32296183 details
SORT_HUMANVAMP5_HUMANIntAct32296183 details
SORT_HUMANBRID5_HUMANBioGRID, IntAct32296183 details
SORT_HUMANCNIH3_HUMANBioGRID, IntAct32296183 details
SORT_HUMANTRFE_HUMANBioGRID, IntAct32296183 details
SORT_HUMANBDNF_HUMANBioGRID, DIP, HPRD, IntAct15987945 19122660 20159974 21357693 32296183 details
SORT_HUMANAGRG7_HUMANBioGRID, IntAct32296183 details
SORT_HUMANSORT_HUMANDIP19122660 details
SORT_HUMANCNTF_HUMANIntAct20584990 details
SORT_HUMANCTF1_HUMANIntAct20584990 details
SORT_HUMANLIF_HUMANIntAct20584990 details
SORT_HUMANONCM_HUMANIntAct20584990 details
SORT_HUMANLIFR_HUMANIntAct20584990 details
SORT_HUMANIL6_HUMANIntAct25401472 details
SORT_HUMANSORC1_HUMANBioGRID, IntAct12482870 24128306 details
SORT_HUMANAGAL_HUMANIntAct21949853 details
SORT_HUMANTHYG_HUMANIntAct18687776 details
SORT_HUMANVPS29_HUMANIntAct32814053 details
SORT_HUMANSORL_HUMANBioGRID11294867 details
SORT_HUMANNTF3_HUMANBioGRID21261755 details
SORT_HUMANTNR16_HUMANbhf-ucl, BioGRID, HPRD14985763 20159974 21261755 details
SORT_HUMANA4_HUMANUniProt23283322 details
SORT_HUMANGGA3_HUMANBioGRID11390366 details
SORT_HUMANSTAM1_HUMANBioGRID11390366 details
SORT_HUMANBACE1_HUMANBioGRID21245145 details
SORT_HUMANHAP1_HUMANBioGRID21357693 details