Entity Details

Primary name NPAS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99743
EntryNameNPAS2_HUMAN
FullNameNeuronal PAS domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length824
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesNPAS2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0007417 central nervous system development
GO:0007623 circadian rhythm
GO:0032922 circadian regulation of gene expression
GO:0042493 response to drug
GO:0045739 positive regulation of DNA repair
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0051775 response to redox state
GO:0051879 Hsp90 protein binding
GO:0060548 negative regulation of cell death
GO:1990513 CLOCK-BMAL transcription complex
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000987 positive regulation of behavioral fear response
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001067 Nuclear translocatorFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608516 OMIMMajor depressive disorder (MDD)A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
NPAS2_HUMANRL6_HUMANBioGRID, IntAct21988832 details
NPAS2_HUMANCSK2B_HUMANBioGRID, IntAct23555304 details
NPAS2_HUMANBHE40_HUMANIntAct23555304 details
NPAS2_HUMANRORG_HUMANBioGRID, IntAct23555304 details
NPAS2_HUMANRASF7_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANHGS_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANEFS_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANCRX_HUMANBioGRID, IntAct24722188 details
NPAS2_HUMANBMAL2_HUMANBioGRID, IntAct24722188 28514442 32296183 details
NPAS2_HUMANBMAL1_HUMANBioGRID, HPRD, IntAct11439184 20211142 23555304 24722188 28514442 32296183 9576906 details
NPAS2_HUMANNCK2_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANNGLY1_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANBPIA1_HUMANBioGRID, IntAct32296183 details
NPAS2_HUMANFGFR3_HUMANIntAct32814053 details
NPAS2_HUMANNMDE3_HUMANIntAct32814053 details
NPAS2_HUMANRHXF1_HUMANBioGRID, IntAct20211142 details
NPAS2_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
NPAS2_HUMANHESX1_HUMANBioGRID, IntAct20211142 details
NPAS2_HUMANEP300_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANNCOA3_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANKAT2B_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANCBP_HUMANBioGRID, HPRD14645221 details
NPAS2_HUMANRXRA_HUMANBioGRID, HPRD11439184 details
NPAS2_HUMANRARA_HUMANBioGRID, HPRD11439184 details
NPAS2_HUMANHS90A_HUMANBioGRID, HPRD9079689 details
NPAS2_HUMANTRAF4_HUMANBioGRID16969126 details
NPAS2_HUMANARNT2_HUMANBioGRID24722188 details
NPAS2_HUMANCLOCK_HUMANBioGRID23555304 details
NPAS2_HUMANCRY1_HUMANBioGRID23555304 details
NPAS2_HUMANCRY2_HUMANBioGRID23555304 details