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Entity Details
Primary name
SHIP2_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
O15357
EntryName
SHIP2_HUMAN
FullName
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
TaxID
9606
Evidence
evidence at protein level
Length
1258
SequenceStatus
complete
DateCreated
2007-09-11
DateModified
2021-06-02
Ontological Relatives
Genes
INPPL1
GO terms
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GO
Name
GO:0001958
endochondral ossification
GO:0002376
immune system process
GO:0003779
actin binding
GO:0005634
nucleus
GO:0005794
Golgi apparatus
GO:0005829
cytosol
GO:0005856
cytoskeleton
GO:0005886
plasma membrane
GO:0006006
glucose metabolic process
GO:0006661
phosphatidylinositol biosynthetic process
GO:0006897
endocytosis
GO:0007015
actin filament organization
GO:0007155
cell adhesion
GO:0008285
negative regulation of cell population proliferation
GO:0009791
post-embryonic development
GO:0010629
negative regulation of gene expression
GO:0016607
nuclear speck
GO:0017124
SH3 domain binding
GO:0019221
cytokine-mediated signaling pathway
GO:0030027
lamellipodium
GO:0030175
filopodium
GO:0032868
response to insulin
GO:0034485
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0042169
SH2 domain binding
GO:0043647
inositol phosphate metabolic process
GO:0046856
phosphatidylinositol dephosphorylation
GO:0097178
ruffle assembly
Subcellular Location
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Subcellular Location
Cell projection
Cytoplasm
Membrane
Nucleus
Nucleus speckle
Domains
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Domain
Name
Category
Type
IPR000300
Inositol polyphosphate-related phosphatase
Domain
Domain
IPR000980
SH2 domain
Domain
Domain
IPR001660
Sterile alpha motif domain
Domain
Domain
IPR005135
Endonuclease/exonuclease/phosphatase
Domain
Domain
IPR013761
Sterile alpha motif/pointed domain superfamily
Family
Homologous superfamily
IPR036691
Endonuclease/exonuclease/phosphatase superfamily
Family
Homologous superfamily
IPR036860
SH2 domain superfamily
Family
Homologous superfamily
Diseases
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Drugs
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Interactions
32 interactions
Interactor
Partner
Sources
Publications
Link
SHIP2_HUMAN
ITSN1_HUMAN
MINT
18692052
details
SHIP2_HUMAN
HID1_HUMAN
BioGRID, IntAct
20368287
details
SHIP2_HUMAN
SRBS1_HUMAN
BioGRID, HPRD, IntAct
12504111
details
SHIP2_HUMAN
ABI1_HUMAN
MINT
20598684
details
SHIP2_HUMAN
VINEX_HUMAN
HPRD, MINT
16302969
details
SHIP2_HUMAN
CD4_HUMAN
BioGRID, IntAct
21988832
details
SHIP2_HUMAN
BCAR1_HUMAN
BioGRID, HPRD, mbinfo
11158326
details
SHIP2_HUMAN
ANDR_HUMAN
BioGRID, IntAct
24728074
details
SHIP2_HUMAN
GAB1_HUMAN
BioGRID, IntAct
24728074
details
SHIP2_HUMAN
MET_HUMAN
BioGRID, HPRD, IntAct
15735664
19713535
24728074
details
SHIP2_HUMAN
EPHA2_HUMAN
DIP
22244754
details
SHIP2_HUMAN
EPHA1_HUMAN
DIP
22244754
details
SHIP2_HUMAN
EGFR_HUMAN
BioGRID, HPRD, IntAct
11349134
19713535
22973453
31585087
details
SHIP2_HUMAN
FLNC_HUMAN
BioGRID, HPRD
11739414
details
SHIP2_HUMAN
UBC_HUMAN
BioGRID
19880507
details
SHIP2_HUMAN
ARAP3_HUMAN
BioGRID
17314030
details
SHIP2_HUMAN
ERBB2_HUMAN
BioGRID
22973453
details
SHIP2_HUMAN
ERBB3_HUMAN
BioGRID
22973453
details
SHIP2_HUMAN
ERBB4_HUMAN
BioGRID
22973453
details
SHIP2_HUMAN
CSF1R_HUMAN
HPRD
15735664
details
SHIP2_HUMAN
CBL_HUMAN
BioGRID, HPRD, IntAct
12504111
15668240
19380743
19880507
details
SHIP2_HUMAN
SHC1_HUMAN
BioGRID, HPRD, IntAct
10194451
11349134
19380743
9660833
details
SHIP2_HUMAN
ABL1_HUMAN
BioGRID, HPRD
10194451
19380743
details
SHIP2_HUMAN
INSR_HUMAN
BioGRID
12504111
17620296
details
SHIP2_HUMAN
SH3K1_HUMAN
BioGRID
17314030
19531213
details
SHIP2_HUMAN
SH2B2_HUMAN
BioGRID
17620296
details
SHIP2_HUMAN
LRRK1_HUMAN
BioGRID
20697350
details
SHIP2_HUMAN
ITA4_HUMAN
BioGRID
22623428
details
SHIP2_HUMAN
CD2AP_HUMAN
BioGRID
17314030
details
SHIP2_HUMAN
SMAG2_HUMAN
BioGRID
29395067
details
SHIP2_HUMAN
SRC_HUMAN
HPRD
12235291
details
SHIP2_HUMAN
FCG2B_HUMAN
HPRD
10789675
details
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