Entity Details

Primary name SLK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H2G2
EntryNameSLK_HUMAN
FullNameSTE20-like serine/threonine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length1235
SequenceStatuscomplete
DateCreated2006-05-02
DateModified2021-06-02

Ontological Relatives

GenesSLK

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006915 apoptotic process
GO:0030334 regulation of cell migration
GO:0031122 cytoplasmic microtubule organization
GO:0031252 cell leading edge
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0045296 cadherin binding
GO:0046777 protein autophosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051893 regulation of focal adhesion assembly
GO:0070062 extracellular exosome
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001943 UVR domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR022165 Polo kinase kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB07664 K-00546Drugbanksmall molecule
DB07853 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrileDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule