Entity Details

Primary name NMDE4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15399
EntryNameNMDE4_HUMAN
FullNameGlutamate receptor ionotropic, NMDA 2D
TaxID9606
Evidenceevidence at protein level
Length1336
SequenceStatuscomplete
DateCreated2001-08-29
DateModified2021-06-02

Ontological Relatives

GenesGRIN2D

GO terms

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GOName
GO:0001964 startle response
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 NMDA glutamate receptor activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007420 brain development
GO:0008344 adult locomotory behavior
GO:0015276 ligand-gated ion channel activity
GO:0017146 NMDA selective glutamate receptor complex
GO:0022849 glutamate-gated calcium ion channel activity
GO:0038023 signaling receptor activity
GO:0048167 regulation of synaptic plasticity
GO:0051930 regulation of sensory perception of pain
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098839 postsynaptic density membrane
GO:0098976 excitatory chemical synaptic transmission

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00659 AcamprosateDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00874 GuaifenesinDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01173 OrphenadrineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01520 TenocyclidineDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB04896 MilnacipranDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06741 GavestinelDrugbanksmall molecule
DB09409 Magnesium acetate tetrahydrateDrugbanksmall molecule
DB09481 Magnesium carbonateDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB13146 Fluciclovine (18F)Drugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
NMDE4_HUMANDLG4_HUMANHPRD, MINT11937501 7569905 details
NMDE4_HUMANCRK_HUMANIntAct17474147 details
NMDE4_HUMANDLG1_HUMANIntAct30126976 details
NMDE4_HUMANIL16_HUMANHPRD10479680 details
NMDE4_HUMANNEDD4_HUMANBioGRID23639431 details
NMDE4_HUMANNMDZ1_HUMANBioGRID, HPRD12191494 18233995 details
NMDE4_HUMANKPCB_HUMANHPRD10862698 details
NMDE4_HUMANKPCE_HUMANHPRD10862698 details
NMDE4_HUMANKPCG_HUMANHPRD10862698 details
NMDE4_HUMANRAP2A_HUMANHPRD10862698 details
NMDE4_HUMANSPTN1_HUMANHPRD10862698 details
NMDE4_HUMANABL1_HUMANHPRD10777567 details
NMDE4_HUMANRASH_HUMANHPRD10862698 details
NMDE4_HUMANKS6A3_HUMANHPRD10862698 details
NMDE4_HUMANZO1_HUMANHPRD10862698 details
NMDE4_HUMANMP2K2_HUMANHPRD10862698 details
NMDE4_HUMANTRAF3_HUMANHPRD10862698 details
NMDE4_HUMANCADH2_HUMANHPRD10862698 details
NMDE4_HUMANDYN1_HUMANHPRD10862698 details
NMDE4_HUMANDUS4_HUMANHPRD10862698 details
NMDE4_HUMANHNRPU_HUMANHPRD10862698 details
NMDE4_HUMANDLG2_HUMANHPRD10862698 details
NMDE4_HUMANAINX_HUMANHPRD10862698 details
NMDE4_HUMAN2ABA_HUMANHPRD10862698 details
NMDE4_HUMANCTRO_HUMANHPRD10862698 details
NMDE4_HUMANSYGP1_HUMANHPRD10862698 details
NMDE4_HUMAN2AAA_HUMANHPRD10862698 details
NMDE4_HUMANNANO1_HUMANHPRD10862698 details
NMDE4_HUMANDLGP4_HUMANHPRD10862698 details
NMDE4_HUMANCTNB1_HUMANHPRD10862698 details
NMDE4_HUMANCLH1_HUMANHPRD10862698 details
NMDE4_HUMANFUS_HUMANHPRD10862698 details
NMDE4_HUMANHS71A_HUMANHPRD10862698 details
NMDE4_HUMANHS71B_HUMANHPRD10862698 details
NMDE4_HUMANNF1_HUMANHPRD10862698 details