Entity Details

Primary name ATS10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H324
EntryNameATS10_HUMAN
FullNameA disintegrin and metalloproteinase with thrombospondin motifs 10
TaxID9606
Evidenceevidence at protein level
Length1103
SequenceStatuscomplete
DateCreated2001-12-05
DateModified2021-06-02

Ontological Relatives

GenesADAMTS10

GO terms

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GOName
GO:0001527 microfibril
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0046872 metal ion binding
GO:0062023 collagen-containing extracellular matrix

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR010294 ADAM-TS Spacer 1DomainDomain
IPR010909 PLACDomainDomain
IPR013273 ADAMTS/ADAMTS-likeFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR041645 ADAM cysteine-rich domain 2DomainDomain

Diseases

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Disease IDSourceNameDescription
277600 OMIMWeill-Marchesani syndrome 1 (WMS1)A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. The disease is caused by variants affecting the gene represented in this entry.