Entity Details

Primary name IL21_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HBE4
EntryNameIL21_HUMAN
FullNameInterleukin-21
TaxID9606
Evidenceevidence at protein level
Length162
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesIL21

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0002314 germinal center B cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005134 interleukin-2 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007165 signal transduction
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0008284 positive regulation of cell population proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0034105 positive regulation of tissue remodeling
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0048469 cell maturation
GO:0050729 positive regulation of inflammatory response
GO:0051607 defense response to virus
GO:0061470 T follicular helper cell differentiation
GO:0098586 cellular response to virus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR003443 Interleukin-15/Interleukin-21 familyFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615767 OMIMImmunodeficiency, common variable, 11 (CVID11)A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. The disease is caused by variants affecting the gene represented in this entry.