Entity Details

Primary name GPVI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HCN6
EntryNameGPVI_HUMAN
FullNamePlatelet glycoprotein VI
TaxID9606
Evidenceevidence at protein level
Length339
SequenceStatuscomplete
DateCreated2006-04-04
DateModified2021-06-02

Ontological Relatives

GenesGP6

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0005518 collagen binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0030168 platelet activation
GO:0038023 signaling receptor activity
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0097197 tetraspanin-enriched microdomain

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614201 OMIMBleeding disorder, platelet-type 11 (BDPLT11)A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. The disease is caused by variants affecting the gene represented in this entry.