Entity Details

Primary name CP26B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NR63
EntryNameCP26B_HUMAN
FullNameCytochrome P450 26B1
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesCYP26B1

GO terms

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GOName
GO:0001709 cell fate determination
GO:0001768 establishment of T cell polarity
GO:0001822 kidney development
GO:0001972 retinoic acid binding
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0006766 vitamin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006954 inflammatory response
GO:0007140 male meiotic nuclear division
GO:0007283 spermatogenesis
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0009954 proximal/distal pattern formation
GO:0010628 positive regulation of gene expression
GO:0016125 sterol metabolic process
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0030326 embryonic limb morphogenesis
GO:0033189 response to vitamin A
GO:0034653 retinoic acid catabolic process
GO:0042573 retinoic acid metabolic process
GO:0043587 tongue morphogenesis
GO:0045580 regulation of T cell differentiation
GO:0048384 retinoic acid receptor signaling pathway
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0060349 bone morphogenesis
GO:0061436 establishment of skin barrier
GO:0070268 cornification
GO:0071300 cellular response to retinoic acid
GO:2001037 positive regulation of tongue muscle cell differentiation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614416 OMIMRadiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)A disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00755 TretinoinDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CP26B_HUMANJPH3_HUMANIntAct32814053 details
CP26B_HUMANNED4L_HUMANBioGRID19953087 details