Entity Details

Primary name GRHPR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBQ7
EntryNameGRHPR_HUMAN
FullNameGlyoxylate reductase/hydroxypyruvate reductase
TaxID9606
Evidenceevidence at protein level
Length328
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesGRHPR

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0007588 excretion
GO:0008465 glycerate dehydrogenase activity
GO:0016618 hydroxypyruvate reductase activity
GO:0019752 carboxylic acid metabolic process
GO:0030267 glyoxylate reductase (NADP+) activity
GO:0042803 protein homodimerization activity
GO:0046487 glyoxylate metabolic process
GO:0051287 NAD binding
GO:0070062 extracellular exosome
GO:0070402 NADPH binding
GO:1902494 catalytic complex

Subcellular Location

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Domains

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DomainNameCategoryType
IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domainDomainDomain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domainDomainDomain
IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
260000 OMIMHyperoxaluria primary 2 (HP2)A disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease. The disease is caused by variants affecting the gene represented in this entry.