Entity Details

Primary name MALT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UDY8
EntryNameMALT1_HUMAN
FullNameMucosa-associated lymphoid tissue lymphoma translocation protein 1
TaxID9606
Evidenceevidence at protein level
Length824
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesMALT1

GO terms

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GOName
GO:0001650 fibrillar center
GO:0001923 B-1 B cell differentiation
GO:0002020 protease binding
GO:0002096 polkadots
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002726 positive regulation of T cell cytokine production
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0006952 defense response
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008233 peptidase activity
GO:0009620 response to fungus
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032449 CBM complex
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032743 positive regulation of interleukin-2 production
GO:0032991 protein-containing complex
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042098 T cell proliferation
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051168 nuclear export
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:2000321 positive regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033540 Mucosa-associated lymphoid tissue lymphoma translocation protein 1FamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037940 MALT1, death domainDomainDomain
IPR041077 MALT1 immunoglobulin-like domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615468 OMIMImmunodeficiency 12 (IMD12)A primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens. The disease is caused by variants affecting the gene represented in this entry.

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
MALT1_HUMANBCL10_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT11090634 11262391 14695475 17189706 17948050 18806265 19118383 19279678 19444310 20551178 21157432 21513986 22267217 22528498 22658522 23690623 24130731 25548215 25569716 25748427 27070702 27071417 27113748 27777308 29953499 30279415 31961340 33329596 details
MALT1_HUMANUBC_HUMANBioGRID, MINT17948050 31980531 details
MALT1_HUMANNEMO_HUMANBioGRID, IntAct, MINT17948050 18931663 19494296 25748427 27070702 details
MALT1_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct, MINT15125833 17948050 19234489 22528498 23264041 25569716 29953499 details
MALT1_HUMANSUV91_HUMANBioGRID, MINT23455924 details
MALT1_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
MALT1_HUMANCARM1_HUMANBioGRID, MINT23455924 details
MALT1_HUMANANM6_HUMANBioGRID, MINT23455924 details
MALT1_HUMANFEM1C_HUMANBioGRID, IntAct32296183 details
MALT1_HUMANFEM1A_HUMANBioGRID, IntAct32296183 details
MALT1_HUMANMALT1_HUMANBioGRID, DIP, HPRD11262391 14695475 19917778 21966355 22158899 22366302 29953499 31961340 details
MALT1_HUMANDYN2_HUMANIntAct32814053 details
MALT1_HUMANGRN_HUMANIntAct32814053 details
MALT1_HUMANHSPB1_HUMANIntAct32814053 details
MALT1_HUMANPAHX_HUMANIntAct32814053 details
MALT1_HUMANPRPS1_HUMANIntAct32814053 details
MALT1_HUMANWFS1_HUMANIntAct32814053 details
MALT1_HUMANBAG6_HUMANIntAct32814053 details
MALT1_HUMANKLF11_HUMANIntAct32814053 details
MALT1_HUMANKIF1B_HUMANIntAct32814053 details
MALT1_HUMANSPRE1_HUMANIntAct32814053 details
MALT1_HUMANATX3_HUMANBioGRID, IntAct29111377 32814053 details
MALT1_HUMANTRAF2_HUMANBioGRID, HPRD15125833 19234489 details
MALT1_HUMANRELB_HUMANBioGRID21873235 31961340 details
MALT1_HUMANUBP2_HUMANBioGRID23264041 28052131 details
MALT1_HUMANHECD3_HUMANBioGRID23358872 details
MALT1_HUMANUB2V2_HUMANBioGRID14695475 details
MALT1_HUMANUBE2N_HUMANBioGRID14695475 details
MALT1_HUMANHOIL1_HUMANBioGRID26525107 33329596 details
MALT1_HUMANSQSTM_HUMANBioGRID, HPRD, MINT16874300 details
MALT1_HUMANVHL_HUMANIntAct17353931 details
MALT1_HUMANKPCT_HUMANBioGRID, MINT17363905 details
MALT1_HUMANTAB2_HUMANBioGRID, MINT17948050 25748427 details
MALT1_HUMANM3K7_HUMANBioGRID, MINT17948050 25748427 details
MALT1_HUMANCAR11_HUMANBioGRID, IntAct, MINT17948050 22528498 23322406 25748427 31961340 33329596 details
MALT1_HUMANCSN5_HUMANBioGRID, MINT19444310 details
MALT1_HUMANCSN1_HUMANBioGRID, MINT19444310 details
MALT1_HUMANCASP8_HUMANInnateDB22267217 details
MALT1_HUMANSHRPN_HUMANBioGRID, IntAct27070702 33329596 details
MALT1_HUMANKPCD_HUMANBioGRID, IntAct22528498 details
MALT1_HUMANKC1A_HUMANBioGRID, DIP19118383 20551178 25088585 details
MALT1_HUMANTRAF3_HUMANIntAct19917778 details
MALT1_HUMANIKBA_HUMANBioGRID20551178 details
MALT1_HUMANKCC2G_HUMANBioGRID21513986 details
MALT1_HUMANDBLOH_HUMANBioGRID19234489 details
MALT1_HUMANDAB2_HUMANBioGRID22323290 details
MALT1_HUMANUSP9X_HUMANBioGRID23690623 details
MALT1_HUMANCHIP_HUMANBioGRID23322406 details
MALT1_HUMANRNF31_HUMANBioGRID24491438 33329596 details
MALT1_HUMANTNAP3_HUMANBioGRID24491438 details
MALT1_HUMANCAR14_HUMANBioGRID27071417 27113748 details
MALT1_HUMANARBK1_HUMANBioGRID31961340 details
MALT1_HUMANCYLD_HUMANBioGRID33329596 details
MALT1_HUMANOTUL_HUMANBioGRID33329596 details