Entity Details
| Primary name |
SARDH_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q9UL12 |
| EntryName | SARDH_HUMAN |
| FullName | Sarcosine dehydrogenase, mitochondrial |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 918 |
| SequenceStatus | complete |
| DateCreated | 2004-09-13 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Mitochondrion matrix |
Domains
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| Domain | Name | Category | Type |
| IPR006076 | FAD dependent oxidoreductase | Domain | Domain |
| IPR006222 | Aminomethyltransferase, folate-binding domain | Domain | Domain |
| IPR013977 | Glycine cleavage T-protein, C-terminal barrel domain | Domain | Domain |
| IPR027266 | GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 | Family | Homologous superfamily |
| IPR029043 | Glycine cleavage T-protein/YgfZ, C-terminal | Family | Homologous superfamily |
| IPR032503 | FAD dependent oxidoreductase, central domain | Domain | Domain |
| IPR036188 | FAD/NAD(P)-binding domain superfamily | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 268900 | OMIM | Sarcosinemia (SARCOS) | A metabolic disorder characterized by an increased concentration of sarcosine in plasma and an increased excretion of sarcosine in urine. Sarcosinemia is most probably a benign condition without significant clinical problems. Some reports have associated sarcosinemia with mental retardation and neurologic problems. The disease is caused by variants affecting the gene represented in this entry. |
Interactions
0 interactions
| Interactor | Partner | Sources | Publications | Link |