Entity Details

Primary name KCC2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQM7
EntryNameKCC2A_HUMAN
FullNameCalcium/calmodulin-dependent protein kinase type II subunit alpha
TaxID9606
Evidenceevidence at protein level
Length478
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesCAMK2A

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000165 MAPK cascade
GO:0002931 response to ischemia
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0014069 postsynaptic density
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0030666 endocytic vesicle membrane
GO:0035254 glutamate receptor binding
GO:0038166 angiotensin-activated signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051346 negative regulation of hydrolase activity
GO:0051928 positive regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060996 dendritic spine development
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1990443 peptidyl-threonine autophosphorylation
GO:2000124 regulation of endocannabinoid signaling pathway
GO:2000310 regulation of NMDA receptor activity
GO:2001222 regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR032710 NTF2-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618095 OMIMMental retardation, autosomal recessive 63 (MRT63)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT63 patients manifest global developmental delay, severe intellectual disability, and seizures. The disease is caused by variants affecting the gene represented in this entry.
617798 OMIMMental retardation, autosomal dominant 53 (MRD53)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04119 Hexatantalum DodecabromideDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule
DB07766 (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

115 interactions

InteractorPartnerSourcesPublicationsLink
KCC2A_HUMANGRIA4_HUMANMINT10366608 details
KCC2A_HUMANACTN1_HUMANBioGRID, IntAct, MINT12223541 25241761 details
KCC2A_HUMANCALM2_HUMANBioGRID, DIP, IntAct17353931 20668654 details
KCC2A_HUMANKCC2D_HUMANBioGRID, DIP, IntAct17353931 20668654 25852190 28514442 29426014 31980649 32296183 details
KCC2A_HUMANKCC2B_HUMANBioGRID, IntAct17353931 27173435 29426014 32296183 unassigned1312 details
KCC2A_HUMANZN363_HUMANBioGRID, MINT17568776 details
KCC2A_HUMANKCC2A_HUMANBioGRID, DIP, IntAct11559703 20668654 21884935 31980649 details
KCC2A_HUMANPPM1F_HUMANBioGRID, MINT11559703 details
KCC2A_HUMANNMDE2_HUMANBioGRID, MINT11459059 16436603 19453375 9694809 details
KCC2A_HUMANKCC2G_HUMANBioGRID, IntAct25852190 31980649 32296183 details
KCC2A_HUMANRM11_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRHXF2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANGLBL2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTEX37_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR151_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANSYVC_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR231_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRALYL_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR193_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANK2C75_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRBPMS_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANK22O_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANCA094_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR197_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANDAZP2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTTC5_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANHYAL3_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANARI5A_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANLENG8_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANSOX5_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRFOX2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANF168A_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTCAF1_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRBPS2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTSR2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANAP2D_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTAB2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANF168B_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR195_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANLASP1_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTIAR_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRBM47_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANCDC37_HUMANBioGRID, IntAct31980649 32296183 details
KCC2A_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
KCC2A_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
KCC2A_HUMANHS90A_HUMANBioGRID, IntAct22939624 31980649 32814053 details
KCC2A_HUMANACTS_HUMANIntAct32814053 details
KCC2A_HUMANAKT1_HUMANBioGRID, IntAct16027165 32814053 details
KCC2A_HUMANAPBB2_HUMANIntAct32814053 details
KCC2A_HUMANAT1A3_HUMANIntAct32814053 details
KCC2A_HUMANBDNF_HUMANIntAct32814053 details
KCC2A_HUMANVPS29_HUMANIntAct32814053 details
KCC2A_HUMANJIP2_HUMANIntAct32814053 details
KCC2A_HUMANUT14A_HUMANIntAct32814053 details
KCC2A_HUMANTOM1_HUMANIntAct32814053 details
KCC2A_HUMANPLPP1_HUMANIntAct32814053 details
KCC2A_HUMANUNG_HUMANIntAct32814053 details
KCC2A_HUMANSHC1_HUMANIntAct32814053 details
KCC2A_HUMANPNPH_HUMANIntAct32814053 details
KCC2A_HUMANNBL1_HUMANIntAct32814053 details
KCC2A_HUMANSMAD3_HUMANIntAct32814053 details
KCC2A_HUMANCBSL_HUMANIntAct32814053 details
KCC2A_HUMANG3P_HUMANIntAct32814053 details
KCC2A_HUMANUBE2K_HUMANIntAct32814053 details
KCC2A_HUMANPECA1_HUMANIntAct32814053 details
KCC2A_HUMANP85A_HUMANIntAct32814053 details
KCC2A_HUMANKPCB_HUMANIntAct32814053 details
KCC2A_HUMANRAB5A_HUMANIntAct32814053 details
KCC2A_HUMANS100B_HUMANIntAct32814053 details
KCC2A_HUMANVIME_HUMANIntAct32814053 details
KCC2A_HUMANCHIP_HUMANIntAct32814053 details
KCC2A_HUMANA4_HUMANIntAct32814053 details
KCC2A_HUMANDLG1_HUMANBioGRID12933808 details
KCC2A_HUMANRIMS1_HUMANBioGRID12871946 details
KCC2A_HUMANATF1_HUMANBioGRID8663317 details
KCC2A_HUMANCREB1_HUMANBioGRID8663317 details
KCC2A_HUMANCD5R1_HUMANBioGRID12223541 details
KCC2A_HUMANACTN4_HUMANBioGRID11160423 details
KCC2A_HUMAN1433B_HUMANBioGRID12619878 details
KCC2A_HUMANPRS8_HUMANBioGRID22496558 details
KCC2A_HUMANTAU_HUMANBioGRID17045592 17512525 details
KCC2A_HUMANSQSTM_HUMANBioGRID14702098 details
KCC2A_HUMANITA2B_HUMANBioGRID1650365 details
KCC2A_HUMANPTTG1_HUMANBioGRID24781523 details
KCC2A_HUMANZBT32_HUMANBioGRID32296183 details
KCC2A_HUMANKR221_HUMANBioGRID32296183 details
KCC2A_HUMANGRIA1_HUMANBioGRID24706758 details
KCC2A_HUMANNR2F6_HUMANIntAct20195357 details
KCC2A_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
KCC2A_HUMANSSBP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANNINL_HUMANBioGRID, IntAct26485645 27173435 unassigned1312 details
KCC2A_HUMANARL3_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANDCTN2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANDCTN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANDBNL_HUMANBioGRID, IntAct29426014 details
KCC2A_HUMANFAK2_HUMANIntAct31413325 details
KCC2A_HUMANFMR1_HUMANIntAct31413325 details
KCC2A_HUMANFXR1_HUMANMINT21653829 details
KCC2A_HUMANPRKN_HUMANBioGRID11679592 details
KCC2A_HUMANHDAC5_HUMANBioGRID18292392 details
KCC2A_HUMANGIT1_HUMANBioGRID18292392 details
KCC2A_HUMAN1433T_HUMANBioGRID18292392 details
KCC2A_HUMANPLCG1_HUMANBioGRID18292392 details
KCC2A_HUMANNOS3_HUMANBioGRID11397791 details
KCC2A_HUMANKCNC1_HUMANBioGRID19213956 details
KCC2A_HUMANSC6A3_HUMANBioGRID22514303 details
KCC2A_HUMANRD23A_HUMANBioGRID23260144 details
KCC2A_HUMANFKBP8_HUMANBioGRID15757646 details
KCC2A_HUMANCYLD_HUMANBioGRID24614225 details
KCC2A_HUMANNMDZ1_HUMANBioGRID9694809 details