Entity Details

Primary name CLD14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95500
EntryNameCLD14_HUMAN
FullNameClaudin-14
TaxID9606
Evidenceevidence at protein level
Length239
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCLDN14

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0007155 cell adhesion
GO:0016021 integral component of membrane
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0042802 identical protein binding
GO:0065003 protein-containing complex assembly
GO:0070830 bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR003556 Claudin-14FamilyFamily
IPR004031 PMP-22/EMP/MP20/Claudin superfamilyFamilyFamily
IPR006187 ClaudinFamilyFamily
IPR017974 Claudin, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
614035 OMIMDeafness, autosomal recessive, 29 (DFNB29)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CLD14_HUMANPKHA1_HUMANBioGRID, IntAct27107012 details
CLD14_HUMANPLLP_HUMANBioGRID, IntAct32296183 details
CLD14_HUMANCTXN3_HUMANBioGRID, IntAct32296183 details
CLD14_HUMANMAL_HUMANBioGRID, IntAct32296183 details