Entity Details

Primary name CAH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00915
EntryNameCAH1_HUMAN
FullNameCarbonic anhydrase 1
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCA1

GO terms

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GOName
GO:0004064 arylesterase activity
GO:0004089 carbonate dehydratase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0015701 bicarbonate transport
GO:0016836 hydro-lyase activity
GO:0035722 interleukin-12-mediated signaling pathway
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001148 Alpha carbonic anhydrase domainDomainDomain
IPR018338 Carbonic anhydrase, alpha-class, conserved siteSiteConserved site
IPR018442 Carbonic anhydrase, CA1FamilyFamily
IPR023561 Carbonic anhydrase, alpha-classFamilyFamily
IPR036398 Alpha carbonic anhydrase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00232 MethyclothiazideDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00310 ChlorthalidoneDrugbanksmall molecule
DB00311 EthoxzolamideDrugbanksmall molecule
DB00381 AmlodipineDrugbanksmall molecule
DB00423 MethocarbamolDrugbanksmall molecule
DB00436 BendroflumethiazideDrugbanksmall molecule
DB00562 BenzthiazideDrugbanksmall molecule
DB00606 CyclothiazideDrugbanksmall molecule
DB00703 MethazolamideDrugbanksmall molecule
DB00774 HydroflumethiazideDrugbanksmall molecule
DB00819 AcetazolamideDrugbanksmall molecule
DB00869 DorzolamideDrugbanksmall molecule
DB00880 ChlorothiazideDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB01021 TrichlormethiazideDrugbanksmall molecule
DB01031 EthinamateDrugbanksmall molecule
DB01119 DiazoxideDrugbanksmall molecule
DB01144 DiclofenamideDrugbanksmall molecule
DB01194 BrinzolamideDrugbanksmall molecule
DB01325 QuinethazoneDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDEDrugbanksmall molecule
DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDDrugbanksmall molecule
DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATEDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB09460 Sodium carbonateDrugbanksmall molecule
DB09472 Sodium sulfateDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
CAH1_HUMANDHB7_HUMANBioGRID, IntAct21988832 details
CAH1_HUMANMK06_HUMANBioGRID, MINT21900206 details
CAH1_HUMANTFCP2_HUMANBioGRID, IntAct25416956 25910212 details