Entity Details

Primary name CO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01024
EntryNameCO3_HUMAN
FullNameComplement C3
TaxID9606
Evidenceevidence at protein level
Length1663
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesC3

GO terms

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GOName
GO:0001798 positive regulation of type IIa hypersensitivity
GO:0001934 positive regulation of protein phosphorylation
GO:0001970 positive regulation of activation of membrane attack complex
GO:0004866 endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0006631 fatty acid metabolic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009617 response to bacterium
GO:0009986 cell surface
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010828 positive regulation of glucose transmembrane transport
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010884 positive regulation of lipid storage
GO:0016322 neuron remodeling
GO:0030449 regulation of complement activation
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035846 oviduct epithelium development
GO:0043312 neutrophil degranulation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050776 regulation of immune response
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0097242 amyloid-beta clearance
GO:0097278 complement-dependent cytotoxicity
GO:0150062 complement-mediated synapse pruning
GO:0150064 vertebrate eye-specific patterning
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling
GO:2000427 positive regulation of apoptotic cell clearance

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000020 Anaphylatoxin/fibulinDomainDomain
IPR001134 Netrin domainDomainDomain
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR001840 Anaphylatoxin, complement system domainDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018081 Anaphylatoxin, complement systemFamilyHomologous superfamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR019742 Alpha-2-macroglobulin, conserved siteSiteConserved site
IPR035711 Complement C3-likeFamilyFamily
IPR035815 Complement C3-like, NTR domainDomainDomain
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041425 Complement C3/4/5, macroglobulin domain MG1DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain

Diseases

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Disease IDSourceNameDescription
613779 OMIMComplement component 3 deficiency (C3D)A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. The disease is caused by variants affecting the gene represented in this entry.
611378 OMIMMacular degeneration, age-related, 9 (ARMD9)A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Disease susceptibility is associated with variants affecting the gene represented in this entry.
612925 OMIMHemolytic uremic syndrome atypical 5 (AHUS5)An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Disease susceptibility is associated with variants affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype.

Drugs

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DrugNameSourceType
DB00028 Human immunoglobulin GDrugbankbiotech
DB01593 ZincDrugbanksmall molecule
DB01915 S-HydroxycysteineDrugbanksmall molecule
DB06492 MirococeptDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
CO3_HUMANVSIG4_HUMANHPRD, IntAct16530040 17051150 details
CO3_HUMANTGM2_HUMANBioGRID, IntAct21988832 details
CO3_HUMANMCP_HUMANHPRD, InnateDB, IntAct1717583 18796626 23086448 details
CO3_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
CO3_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
CO3_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
CO3_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
CO3_HUMANKR108_HUMANBioGRID, IntAct32296183 details
CO3_HUMANFBLN4_HUMANBioGRID, IntAct32296183 details
CO3_HUMANFA20C_HUMANIntAct22582013 details
CO3_HUMANCFAB_HUMANBioGRID, DIP, HPRD10610782 11367533 19255449 8648130 details
CO3_HUMANCFAH_HUMANBioGRID, DIP, HPRD, IntAct11367533 21317894 21979047 9291131 9988761 details
CO3_HUMANHMGB1_HUMANBioGRID, UniProt29721183 details
CO3_HUMANPROP_HUMANBioGRID, HPRD, IntAct11513971 24797388 3421908 details
CO3_HUMANCATG_HUMANHPRD, IntAct1861080 24355864 details
CO3_HUMANFHR4_HUMANBioGRID, HPRD, IntAct10622723 20042240 22518841 details
CO3_HUMANCR1_HUMANHPRD, IntAct10382758 18796626 9988761 details
CO3_HUMANCFAI_HUMANBioGRID, HPRD, IntAct1401896 18796626 8648130 9291131 details
CO3_HUMANDMBT1_HUMANIntAct22811680 details
CO3_HUMANFHR5_HUMANBioGRID, HPRD11058592 details
CO3_HUMANFHR3_HUMANBioGRID, HPRD10622723 details
CO3_HUMANITAX_HUMANBioGRID, HPRD4062888 7512600 details
CO3_HUMANCBPN_HUMANBioGRID, HPRD11939578 details
CO3_HUMANCO5_HUMANBioGRID, HPRD11367533 details
CO3_HUMANITB2_HUMANBioGRID4062888 details
CO3_HUMANA16L1_HUMANBioGRID30293775 details
CO3_HUMANHS90A_HUMANBioGRID31273033 details
CO3_HUMANVHL_HUMANIntAct17353931 details
CO3_HUMANASF1B_HUMANIntAct17353931 details
CO3_HUMANTRFE_HUMANBioGRID, IntAct27173435 unassigned1312 details
CO3_HUMANITAM_HUMANBioGRID, HPRD11073102 23134465 4062888 details
CO3_HUMANLRP1_HUMANHPRD10608878 details
CO3_HUMANCR2_HUMANHPRD11684127 1830068 details
CO3_HUMANCO3_HUMANHPRD10622723 details
CO3_HUMANVTDB_HUMANHPRD2824652 details
CO3_HUMANLAMA1_HUMANHPRD3488995 details
CO3_HUMANPAPP1_HUMANHPRD6203109 details
CO3_HUMANABL1_HUMANHPRD4062888 details
CO3_HUMANMASP1_HUMANHPRD9719152 details
CO3_HUMANC3AR_HUMANHPRD11342658 details
CO3_HUMANOLFM4_HUMANHPRD2824652 details
CO3_HUMANCO2_HUMANHPRD3546307 details
CO3_HUMANC5AR2_HUMANHPRD11773063 details