Entity Details

Primary name CD8A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01732
EntryNameCD8A_HUMAN
FullNameT-cell surface glycoprotein CD8 alpha chain
TaxID9606
Evidenceevidence at protein level
Length235
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCD8A

GO terms

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GOName
GO:0002456 T cell mediated immunity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009897 external side of plasma membrane
GO:0015026 coreceptor activity
GO:0019882 antigen processing and presentation
GO:0023024 MHC class I protein complex binding
GO:0042101 T cell receptor complex
GO:0042110 T cell activation
GO:0042288 MHC class I protein binding
GO:0044853 plasma membrane raft
GO:0045065 cytotoxic T cell differentiation
GO:0050776 regulation of immune response

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015468 CD8 alpha subunitFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608957 OMIMCD8 deficiency, familial (CD8 deficiency)An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. The disease is caused by variants affecting the gene represented in this entry.