Entity Details

Primary name IGHG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01857
EntryNameIGHG1_HUMAN
FullNameImmunoglobulin heavy constant gamma 1
TaxID9606
Evidenceevidence at protein level
Length330
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003823 antigen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0008228 opsonization
GO:0009897 external side of plasma membrane
GO:0018149 peptide cross-linking
GO:0019221 cytokine-mediated signaling pathway
GO:0030449 regulation of complement activation
GO:0034987 immunoglobulin receptor binding
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042571 immunoglobulin complex, circulating
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
GO:0050871 positive regulation of B cell activation
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
254500 OMIMMultiple myeloma (MM)A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Drugs

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DrugNameSourceType
DB01631 Methyl nonanoateDrugbanksmall molecule
DB03740 N-acetyl-alpha-D-glucosamineDrugbanksmall molecule
DB04473 alpha-L-fucoseDrugbanksmall molecule
DB04639 BiphenylalanineDrugbanksmall molecule
DB07371 3-(10-methyl-9-anthryl)propanoic acidDrugbanksmall molecule
DB07375 EtiocholanedioneDrugbanksmall molecule
DB07441 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACIDDrugbanksmall molecule
DB07672 TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDEDrugbanksmall molecule
DB07764 FluorescinDrugbanksmall molecule
DB07816 N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACIDDrugbanksmall molecule
DB07881 N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINEDrugbanksmall molecule
DB07883 (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONEDrugbanksmall molecule
DB07909 (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOLDrugbanksmall molecule
DB08294 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACIDDrugbanksmall molecule
DB08296 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACIDDrugbanksmall molecule
DB08332 9-(2-carboxyethyl)-10-methylanthracene endoperoxideDrugbanksmall molecule
DB08377 N-[4-(4-nitrophenylphospho)butanoyl]-D-alanineDrugbanksmall molecule
DB08394 PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINEDrugbanksmall molecule
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINEDrugbanksmall molecule
DB08410 PARA-NITROBENZYL GLUTARYL GLYCINIC ACIDDrugbanksmall molecule
DB08411 N-[4-(4-nitrophenylphospho)butanoyl]-L-alanineDrugbanksmall molecule
DB08412 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACIDDrugbanksmall molecule
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACIDDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB15258 ImlifidaseDrugbankbiotech