Entity Details

Primary name SODM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04179
EntryNameSODM_HUMAN
FullNameSuperoxide dismutase [Mn], mitochondrial
TaxID9606
Evidenceevidence at protein level
Length222
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesSOD2

GO terms

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GOName
GO:0000303 response to superoxide
GO:0001315 age-dependent response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0001836 release of cytochrome c from mitochondria
GO:0003069 acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
GO:0003677 DNA binding
GO:0004784 superoxide dismutase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006801 superoxide metabolic process
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009409 response to cold
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process
GO:0014823 response to activity
GO:0019430 removal of superoxide radicals
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0030145 manganese ion binding
GO:0030335 positive regulation of cell migration
GO:0032364 oxygen homeostasis
GO:0032496 response to lipopolysaccharide
GO:0033591 response to L-ascorbic acid
GO:0034021 response to silicon dioxide
GO:0034599 cellular response to oxidative stress
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035900 response to isolation stress
GO:0035902 response to immobilization stress
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042645 mitochondrial nucleoid
GO:0042802 identical protein binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0046686 response to cadmium ion
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051289 protein homotetramerization
GO:0051602 response to electrical stimulus
GO:0070062 extracellular exosome
GO:0071000 response to magnetism
GO:0071361 cellular response to ethanol
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902631 negative regulation of membrane hyperpolarization
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1905932 positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001189 Manganese/iron superoxide dismutaseFamilyFamily
IPR019831 Manganese/iron superoxide dismutase, N-terminalDomainDomain
IPR019832 Manganese/iron superoxide dismutase, C-terminalDomainDomain
IPR019833 Manganese/iron superoxide dismutase, binding siteSiteBinding site
IPR036314 Manganese/iron superoxide dismutase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036324 Manganese/iron superoxide dismutase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612634 OMIMMicrovascular complications of diabetes 6 (MVCD6)Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03297 Benzylsulfonic acidDrugbanksmall molecule
DB04436 3-Fluoro-L-tyrosineDrugbanksmall molecule
DB06796 MangafodipirSwissprotsmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB11590 ThimerosalDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
SODM_HUMANRS3A_HUMANBioGRID, HPRD, IntAct16169070 details
SODM_HUMANNOL12_HUMANBioGRID, HPRD, IntAct16169070 details
SODM_HUMANGET4_HUMANHPRD, IntAct16169070 details
SODM_HUMANK1549_HUMANHPRD, IntAct16169070 details
SODM_HUMANSODM_HUMANBioGRID, HPRD, IntAct, MINT10852710 1394426 14638684 19822147 21988832 2738919 details
SODM_HUMANCP4FC_HUMANBioGRID, IntAct21988832 details
SODM_HUMANSTK4_HUMANIntAct23386615 details
SODM_HUMANCEP70_HUMANBioGRID, IntAct32296183 details
SODM_HUMANNAL12_HUMANI2D32226298 details
SODM_HUMANUBP36_HUMANBioGRID21268071 details
SODM_HUMANA4_HUMANBioGRID21832049 details
SODM_HUMANHDHD2_HUMANHPRD16169070 details
SODM_HUMANRAB4A_HUMANHPRD, IntAct123234 16169070 details
SODM_HUMANARF6_HUMANIntAct17353931 details
SODM_HUMANPAK2_HUMANIntAct17353931 details
SODM_HUMANEIF1B_HUMANIntAct17353931 details
SODM_HUMANTNIK_HUMANIntAct17353931 details
SODM_HUMANCRCM_HUMANIntAct17353931 details
SODM_HUMANRIPK2_HUMANIntAct17353931 details
SODM_HUMANVHL_HUMANIntAct17353931 details
SODM_HUMANCYTN_HUMANIntAct17353931 details
SODM_HUMANMYH8_HUMANIntAct17353931 details
SODM_HUMANAMY1B_HUMANIntAct17353931 details
SODM_HUMANAMY1C_HUMANIntAct17353931 details
SODM_HUMANAMY1A_HUMANIntAct17353931 details
SODM_HUMANIKKE_HUMANIntAct17353931 details
SODM_HUMANHLAB_HUMANIntAct17353931 details
SODM_HUMAN3MG_HUMANIntAct17353931 details
SODM_HUMANCYTS_HUMANIntAct17353931 details
SODM_HUMANDC1L1_HUMANIntAct20195357 details
SODM_HUMANPIP30_HUMANIntAct20195357 details
SODM_HUMANPDIA1_HUMANIntAct20195357 details
SODM_HUMANTM131_HUMANIntAct20195357 details
SODM_HUMANRL21_HUMANIntAct20195357 details
SODM_HUMANGOGB1_HUMANIntAct20195357 details
SODM_HUMANENPL_HUMANIntAct20195357 details
SODM_HUMANSMCA2_HUMANIntAct20195357 details
SODM_HUMANPRDM2_HUMANIntAct20195357 details
SODM_HUMANSCRN1_HUMANIntAct20195357 details
SODM_HUMANTCAL9_HUMANIntAct20195357 details
SODM_HUMANSMCA5_HUMANIntAct20195357 details
SODM_HUMANRSCA1_HUMANBioGRID27555600 details