Entity Details

Primary name K1C18_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05783
EntryNameK1C18_HUMAN
FullNameKeratin, type I cytoskeletal 18
TaxID9606
Evidenceevidence at protein level
Length430
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesKRT18

GO terms

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GOName
GO:0003723 RNA binding
GO:0005198 structural molecule activity
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0005912 adherens junction
GO:0007049 cell cycle
GO:0009653 anatomical structure morphogenesis
GO:0009750 response to fructose
GO:0009897 external side of plasma membrane
GO:0016032 viral process
GO:0031424 keratinization
GO:0031667 response to nutrient levels
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034451 centriolar satellite
GO:0043000 Golgi to plasma membrane CFTR protein transport
GO:0043066 negative regulation of apoptotic process
GO:0045095 keratin filament
GO:0045104 intermediate filament cytoskeleton organization
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0070365 hepatocyte differentiation
GO:0072497 mesenchymal stem cell differentiation
GO:0097110 scaffold protein binding
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:1902488 cholangiocyte apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002957 Keratin, type IFamilyFamily
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR027695 Keratin, type I cytoskeletal 18FamilyFamily
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Disease IDSourceNameDescription
215600 OMIMCirrhosis (CIRRH)A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. The disease is caused by variants affecting the gene represented in this entry.

Interactions

105 interactions

InteractorPartnerSourcesPublicationsLink
K1C18_HUMANK2C8_HUMANbhf-ucl, BioGRID, HPRD, IntAct10852826 10954706 11684708 14756564 15731013 21988832 30021884 32296183 34079125 9630597 details
K1C18_HUMANRAF1_HUMANHPRD, MINT15314064 details
K1C18_HUMANK1C15_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
K1C18_HUMANLDOC1_HUMANBioGRID, HPRD, IntAct16189514 details
K1C18_HUMANEXOC8_HUMANBioGRID, HPRD, IntAct16189514 details
K1C18_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
K1C18_HUMANHGS_HUMANBioGRID, HPRD, IntAct16189514 25910212 26871637 32296183 details
K1C18_HUMANNDK7_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
K1C18_HUMANDNJB6_HUMANBioGRID, HPRD, IntAct10954706 details
K1C18_HUMANFIBA_HUMANIntAct10954706 details
K1C18_HUMAN1433T_HUMANBioGRID, IntAct10954706 20618440 9524113 details
K1C18_HUMANTRADD_HUMANBioGRID, HPRD, IntAct11684708 details
K1C18_HUMANBBS1_HUMANBioGRID, IntAct18000879 details
K1C18_HUMANBBS4_HUMANBioGRID, IntAct18000879 details
K1C18_HUMANBBS2_HUMANBioGRID, IntAct18000879 details
K1C18_HUMANBBS7_HUMANBioGRID, IntAct18000879 details
K1C18_HUMANTS101_HUMANBioGRID, IntAct19549727 32296183 details
K1C18_HUMAN1433G_HUMANBioGRID, HPRD, IntAct20936779 9524113 details
K1C18_HUMANGRN_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANCCNI_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANPOTE1_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANCDC5L_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANEP300_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANRASH_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANORC5_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANSMRD1_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANMYOME_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANFRAT1_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANTHIOM_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANTXD11_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANPIAS4_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANYTDC1_HUMANBioGRID, IntAct21988832 details
K1C18_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
K1C18_HUMANPKP2_HUMANbhf-ucl, BioGRID, HPRD10852826 details
K1C18_HUMANPKP1_HUMANbhf-ucl10852826 details
K1C18_HUMANGOGA2_HUMANBioGRID, IntAct25416956 25910212 31515488 details
K1C18_HUMANCC146_HUMANBioGRID, IntAct25416956 details
K1C18_HUMANHAUS1_HUMANBioGRID, IntAct25416956 details
K1C18_HUMANK1C18_HUMANBioGRID, IntAct25416956 details
K1C18_HUMANNFL_HUMANBioGRID, IntAct26871637 details
K1C18_HUMANEFHC1_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANK2C71_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANK2C6A_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANK2C79_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANCA109_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANK2C6C_HUMANBioGRID, IntAct30021884 32296183 details
K1C18_HUMANRCOR3_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANKIFC3_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANKRT81_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANCCHCR_HUMANBioGRID, IntAct32296183 details
K1C18_HUMANSYCE1_HUMANBioGRID, IntAct25910212 details
K1C18_HUMANMACD1_HUMANIntAct20035625 details
K1C18_HUMANHD_HUMANIntAct32814053 details
K1C18_HUMANCBL_HUMANBioGRID, HPRD9367879 details
K1C18_HUMANGCP4_HUMANBioGRID, HPRD16189514 details
K1C18_HUMANPKP3_HUMANBioGRID12707304 details
K1C18_HUMANTNR1B_HUMANBioGRID, HPRD10747083 details
K1C18_HUMANPKD1_HUMANBioGRID, HPRD11581269 details
K1C18_HUMANHSP74_HUMANBioGRID7529764 details
K1C18_HUMANCOHA1_HUMANBioGRID, HPRD10022517 details
K1C18_HUMANK2C72_HUMANBioGRID9630597 details
K1C18_HUMANPININ_HUMANBioGRID, HPRD10809736 details
K1C18_HUMANSVIL_HUMANBioGRID, HPRD20309963 details
K1C18_HUMANZN363_HUMANBioGRID19282868 details
K1C18_HUMANRENT2_HUMANBioGRID15231747 details
K1C18_HUMANESR1_HUMANBioGRID20348541 details
K1C18_HUMANWBP2_HUMANBioGRID27578003 details
K1C18_HUMANPPIP2_HUMANBioGRID26871637 details
K1C18_HUMANTCHP_HUMANBioGRID, HPRD15731013 15731014 34079125 details
K1C18_HUMANPAI1_HUMANHPRD15493875 details
K1C18_HUMANUSH2A_HUMANHPRD276901 details
K1C18_HUMANRHPN2_HUMANHPRD12473120 details
K1C18_HUMANSHC1_HUMANHPRD, IntAct12577067 details
K1C18_HUMAN1433Z_HUMANHPRD, MINT11917136 15314064 19357195 20618440 9524113 details
K1C18_HUMANLIRB3_HUMANIntAct26769854 details
K1C18_HUMANBECN1_HUMANDIP23112296 details
K1C18_HUMANARP3_HUMANMINT14710194 details
K1C18_HUMANFXR1_HUMANMINT21653829 details
K1C18_HUMANFXR2_HUMANMINT21653829 details
K1C18_HUMANK2C5_HUMANBioGRID, HPRD9786957 details
K1C18_HUMANDEDD_HUMANBioGRID, HPRD12235123 details
K1C18_HUMANKPCE_HUMANBioGRID, HPRD1374067 15368451 7523419 details
K1C18_HUMANALK_HUMANBioGRID14968112 details
K1C18_HUMANCADH1_HUMANBioGRID16212417 25468996 details
K1C18_HUMANEGFR_HUMANBioGRID, HPRD12577067 26320552 details
K1C18_HUMANEIF3H_HUMANBioGRID32269044 details
K1C18_HUMAN1433F_HUMANHPRD9524113 details
K1C18_HUMANCDK1_HUMANHPRD15368451 9524113 details
K1C18_HUMANTBG1_HUMANHPRD10444072 details
K1C18_HUMANCASP8_HUMANHPRD10891503 details
K1C18_HUMANCASP3_HUMANHPRD11356849 12235123 9298992 details
K1C18_HUMANCASP6_HUMANHPRD9298992 details
K1C18_HUMANCASP7_HUMANHPRD9298992 details
K1C18_HUMANBIP_HUMANHPRD9409741 details
K1C18_HUMANKPCA_HUMANHPRD1374067 7523419 details
K1C18_HUMANKS6A3_HUMANHPRD1374067 7523419 details
K1C18_HUMANMK14_HUMANHPRD11788583 details
K1C18_HUMAN1433B_HUMANHPRD9524113 details
K1C18_HUMAN1433E_HUMANHPRD9524113 details
K1C18_HUMANHS71A_HUMANHPRD7529764 details
K1C18_HUMANHS71B_HUMANHPRD7529764 details