Entity Details

Primary name INSR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06213
EntryNameINSR_HUMAN
FullNameInsulin receptor
TaxID9606
Evidenceevidence at protein level
Length1382
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesINSR

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001540 amyloid-beta binding
GO:0001934 positive regulation of protein phosphorylation
GO:0002092 positive regulation of receptor internalization
GO:0003007 heart morphogenesis
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005198 structural molecule activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0005975 carbohydrate metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007612 learning
GO:0007613 memory
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0010008 endosome membrane
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019087 transformation of host cell by virus
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0032869 cellular response to insulin stimulus
GO:0033674 positive regulation of kinase activity
GO:0038024 cargo receptor activity
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043410 positive regulation of MAPK cascade
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045995 regulation of embryonic development
GO:0046326 positive regulation of glucose import
GO:0046777 protein autophosphorylation
GO:0048639 positive regulation of developmental growth
GO:0051425 PTB domain binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060267 positive regulation of respiratory burst
GO:0070062 extracellular exosome
GO:0097062 dendritic spine maintenance
GO:0097242 amyloid-beta clearance
GO:0150104 transport across blood-brain barrier
GO:1990535 neuron projection maintenance

Subcellular Location

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Subcellular Location
Cell membrane
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily
IPR040969 Insulin receptor, trans-membrane domainDomainDomain

Diseases

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Disease IDSourceNameDescription
609968 OMIMFamilial hyperinsulinemic hypoglycemia 5 (HHF5)Familial hyperinsulinemic hypoglycemia [MIM:256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. The disease is caused by variants affecting the gene represented in this entry.
246200 OMIMLeprechaunism (LEPRCH)Represents the most severe form of insulin resistance syndrome, characterized by intrauterine and postnatal growth retardation and death in early infancy. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.
610549 OMIMInsulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A)Characterized by the association of severe insulin resistance (manifested by marked hyperinsulinemia and a failure to respond to exogenous insulin) with the skin lesion acanthosis nigricans and ovarian hyperandrogenism in adolescent female subjects. Women frequently present with hirsutism, acne, amenorrhea or oligomenorrhea, and virilization. This syndrome is different from the type B that has been demonstrated to be secondary to the presence of circulating autoantibodies against the insulin receptor. The disease is caused by variants affecting the gene represented in this entry.
262190 OMIMRabson-Mendenhall syndrome (RMS)Severe insulin resistance syndrome characterized by insulin-resistant diabetes mellitus with pineal hyperplasia and somatic abnormalities. Typical features include coarse, senile-appearing facies, dental and skin abnormalities, abdominal distension, and phallic enlargement. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.
125853 OMIMDiabetes mellitus, non-insulin-dependent (NIDDM)A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. The gene represented in this entry may be involved in disease pathogenesis.

Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00046 Insulin lisproDrugbankbiotech
DB00047 Insulin glargineDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB01277 MecaserminDrugbankbiotech
DB01306 Insulin aspartDrugbankbiotech
DB01307 Insulin detemirDrugbankbiotech
DB01309 Insulin glulisineDrugbankbiotech
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateDrugbanksmall molecule
DB05115 NN344Drugbanksmall molecule
DB05120 AT1391Drugbanksmall molecule
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDrugbanksmall molecule
DB09129 Chromic chlorideDrugbanksmall molecule
DB09564 Insulin degludecDrugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB14751 Mecasermin rinfabateDrugbankbiotech

Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
INSR_HUMANMD2L1_HUMANBioGRID, HPRD, IntAct, MINT32296183 9092546 details
INSR_HUMANGRB10_HUMANBioGRID, DIP, HPRD, MINT10871840 12493740 12551896 15664450 19648926 7479769 8621530 9006901 9369444 9506989 details
INSR_HUMANIRS2_HUMANBioGRID, HPRD, MINT8626379 8662806 9195949 details
INSR_HUMANIRS1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10455177 11606564 11781100 15629149 16582879 17167487 25667086 7499194 7935368 8626379 8662806 details
INSR_HUMANCRKL_HUMANHPRD, IntAct15522217 details
INSR_HUMANCRK_HUMANHPRD, IntAct15522217 details
INSR_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT10482988 10764799 10803466 10816433 10896916 10921922 11075717 12237775 15629149 7499194 8702728 9083103 9121430 9446569 9593725 9710204 9741627 details
INSR_HUMAN1433B_HUMANHPRD, IntAct15629149 details
INSR_HUMANGRB14_HUMANBioGRID, DIP, HPRD, IntAct, MINT11726652 16582879 16934761 19648926 24535599 details
INSR_HUMANPTN1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11163213 11506178 11579209 11726652 12237455 12634852 14722096 15588987 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 8826975 8999839 9355745 details
INSR_HUMANPLCG1_HUMANBioGRID, HPRD, MINT11796522 14568990 22974441 9593725 details
INSR_HUMANP85A_HUMANBioGRID, HPRD, MINT10500481 11796522 1334490 14729945 15629149 7659087 8276809 8385099 8567177 9593725 details
INSR_HUMANPTN11_HUMANBioGRID, HPRD, MINT7493946 8135823 8895367 9593725 details
INSR_HUMANPTPRC_HUMANHPRD, IntAct1373652 19167335 details
INSR_HUMANPTPRK_HUMANBioGRID, IntAct19167335 26186194 28514442 details
INSR_HUMANPTPRG_HUMANIntAct19167335 details
INSR_HUMANPTPRB_HUMANIntAct19167335 details
INSR_HUMANPTPRJ_HUMANIntAct19167335 details
INSR_HUMANPTPRO_HUMANIntAct19167335 details
INSR_HUMANPTN12_HUMANHPRD, IntAct19167335 8454633 details
INSR_HUMANSTA5B_HUMANBioGRID, HPRD, MINT10830280 12456798 9122188 9428692 details
INSR_HUMANSH2B1_HUMANBioGRID, HPRD, MINT10594240 15767667 9742218 details
INSR_HUMANIRF7_HUMANBioGRID, IntAct21988832 details
INSR_HUMANTEAD1_HUMANBioGRID, IntAct21988832 details
INSR_HUMANENPP1_HUMANbhf-ucl, BioGRID, HPRD10615944 11289049 details
INSR_HUMANIGF1_HUMANbhf-ucl, DIP26027733 8452530 details
INSR_HUMANPGS2_HUMANmatrixdb24389353 details
INSR_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
INSR_HUMANINSR_HUMANBioGRID, DIP, HPRD11401470 16271887 16957736 18278056 2033070 23302862 26853939 29512653 7806540 8496180 8504096 details
INSR_HUMANARRB2_HUMANBioGRID, DIP19122674 details
INSR_HUMANINS_HUMANDIP, HPRD23302862 2550426 29512653 details
INSR_HUMANPTN3_HUMANDIP25728925 details
INSR_HUMANDUS18_HUMANBioGRID, MINT28065597 details
INSR_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
INSR_HUMANSTYX_HUMANBioGRID, MINT28065597 details
INSR_HUMANDUS19_HUMANBioGRID, MINT28065597 details
INSR_HUMANCSK_HUMANBioGRID, HPRD10026153 details
INSR_HUMANFRS2_HUMANBioGRID, HPRD10650943 details
INSR_HUMANSOCS3_HUMANBioGRID, HPRD11071852 12560330 15514089 details
INSR_HUMANFETUA_HUMANBioGRID, HPRD7906861 details
INSR_HUMANRASH_HUMANBioGRID, HPRD3109943 details
INSR_HUMANSMAD2_HUMANBioGRID, HPRD9092546 details
INSR_HUMANVAV_HUMANBioGRID, HPRD7535775 details
INSR_HUMANGRB7_HUMANBioGRID, HPRD10803466 details
INSR_HUMANHNRPQ_HUMANBioGRID, HPRD11994298 details
INSR_HUMANSH2B2_HUMANBioGRID, HPRD10196204 15031295 17620296 details
INSR_HUMANSOCS1_HUMANBioGRID, HPRD11342531 15169905 29991678 details
INSR_HUMANDOK1_HUMANBioGRID, HPRD11551902 details
INSR_HUMANSQSTM_HUMANBioGRID26043024 9564850 details
INSR_HUMANMARH1_HUMANBioGRID27577745 details
INSR_HUMANCHIP_HUMANBioGRID28431247 details
INSR_HUMANGRDN_HUMANBioGRID25187647 details
INSR_HUMANERBB2_HUMANBioGRID30898150 details
INSR_HUMANTRI72_HUMANBioGRID30586741 details
INSR_HUMANSOCS2_HUMANHPRD10453981 details
INSR_HUMANGAB1_HUMANHPRD10978177 9658397 details
INSR_HUMANP55G_HUMANHPRD9524259 details
INSR_HUMANSRBS1_HUMANBioGRID, HPRD, IntAct11374898 details
INSR_HUMANRHOB_HUMANBioGRID, MINT14722096 34079125 details
INSR_HUMANRASA1_HUMANBioGRID, HPRD, MINT1331107 9593725 details
INSR_HUMANAGAP2_HUMANMINT21720388 details
INSR_HUMANPTN2_HUMANHPRD, MINT12612081 15192089 15588985 details
INSR_HUMANPTN6_HUMANBioGRID, HPRD, MINT12468540 28065597 7512963 8114715 8692915 details
INSR_HUMANDUS14_HUMANMINT28065597 details
INSR_HUMANASM3B_HUMANIntAct31217420 details
INSR_HUMANCAV1_HUMANBioGRID, HPRD, IntAct10598578 31217420 details
INSR_HUMANMK01_HUMANBioGRID11409918 details
INSR_HUMANMK03_HUMANBioGRID, HPRD11409918 details
INSR_HUMANKHDR1_HUMANBioGRID, HPRD10437794 11604231 details
INSR_HUMANGRB2_HUMANBioGRID9083103 details
INSR_HUMANKPCD_HUMANBioGRID, HPRD11266508 12031982 details
INSR_HUMANVAV3_HUMANBioGRID, HPRD11094073 details
INSR_HUMANINSRR_HUMANBioGRID, HPRD8916919 details
INSR_HUMANSHIP2_HUMANBioGRID12504111 17620296 details
INSR_HUMANSNX6_HUMANBioGRID, HPRD11279102 details
INSR_HUMANSNX1_HUMANBioGRID, HPRD9819414 details
INSR_HUMANSNX2_HUMANBioGRID, HPRD9819414 details
INSR_HUMANSNX4_HUMANBioGRID, HPRD9819414 details
INSR_HUMANJAK2_HUMANBioGRID, HPRD12456798 8912646 details
INSR_HUMANHGS_HUMANBioGRID17445799 details
INSR_HUMANSOCS6_HUMANBioGRID, HPRD11342531 details
INSR_HUMANSTA5A_HUMANBioGRID, HPRD12456798 details
INSR_HUMANJAK1_HUMANBioGRID, HPRD12456798 9492017 details
INSR_HUMANSNX17_HUMANBioGRID23382219 details
INSR_HUMANSNX27_HUMANBioGRID23382219 details
INSR_HUMANPUR9_HUMANBioGRID25687571 details
INSR_HUMANHACD3_HUMANBioGRID25687571 details
INSR_HUMANAAPK1_HUMANBioGRID25687571 details
INSR_HUMANAAPK2_HUMANBioGRID25687571 details
INSR_HUMANKIF5A_HUMANBioGRID25687571 details
INSR_HUMANPPM1A_HUMANBioGRID28065597 details
INSR_HUMANPPM1F_HUMANBioGRID28065597 details
INSR_HUMANMPZL2_HUMANBioGRID28065597 details
INSR_HUMANSSH1_HUMANBioGRID28065597 details
INSR_HUMANPPAC_HUMANBioGRID, HPRD1304913 9299573 details
INSR_HUMANIGF1R_HUMANBioGRID, HPRD27684187 7895674 details
INSR_HUMANRIN1_HUMANBioGRID12783862 details
INSR_HUMANRACK1_HUMANBioGRID, HPRD11964397 16382134 details
INSR_HUMANADRB2_HUMANHPRD8557631 details
INSR_HUMANCALM1_HUMANHPRD12153558 8639568 details
INSR_HUMANCALM2_HUMANHPRD12153558 8639568 details
INSR_HUMANCALM3_HUMANHPRD12153558 8639568 details
INSR_HUMANARF1_HUMANHPRD9197239 details
INSR_HUMANCEAM1_HUMANHPRD10805733 11694516 7592607 7626603 details
INSR_HUMANSRC_HUMANHPRD15337529 details
INSR_HUMANCAV3_HUMANHPRD9756945 details
INSR_HUMANRHG26_HUMANHPRD7836419 details
INSR_HUMANDOK4_HUMANHPRD12730241 details
INSR_HUMANIGF2_HUMANHPRD9722981 details
INSR_HUMANRAF1_HUMANHPRD11409918 details
INSR_HUMANCBL_HUMANHPRD10635327 11997497 details
INSR_HUMANKPCA_HUMANHPRD7926007 8463287 details
INSR_HUMANPTPRF_HUMANHPRD11158333 1321126 15588985 details
INSR_HUMANFABP4_HUMANHPRD1648089 8463311 details
INSR_HUMANDOK5_HUMANHPRD12730241 details
INSR_HUMANK1C27_HUMANHPRD15629149 details