Entity Details

Primary name SPRC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09486
EntryNameSPRC_HUMAN
FullNameSPARC
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesSPARC

GO terms

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GOName
GO:0001503 ossification
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002576 platelet degranulation
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0007507 heart development
GO:0009629 response to gravity
GO:0009986 cell surface
GO:0010288 response to lead ion
GO:0010595 positive regulation of endothelial cell migration
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0022604 regulation of cell morphogenesis
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0031091 platelet alpha granule
GO:0031092 platelet alpha granule membrane
GO:0031093 platelet alpha granule lumen
GO:0032496 response to lipopolysaccharide
GO:0033591 response to L-ascorbic acid
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0048839 inner ear development
GO:0048856 anatomical structure development
GO:0050807 regulation of synapse organization
GO:0050840 extracellular matrix binding
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0071682 endocytic vesicle lumen
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001999 Osteonectin-like, conserved siteSiteConserved site
IPR002350 Kazal domainDomainDomain
IPR003645 Follistatin-like, N-terminalDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015369 Follistatin/Osteonectin EGF domainDomainDomain
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR019577 SPARC/Testican, calcium-binding domainDomainDomain
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR037641 SPARCFamilyFamily

Diseases

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Disease IDSourceNameDescription
616507 OMIMOsteogenesis imperfecta 17 (OI17)An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule