Entity Details

Primary name G6PD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11413
EntryNameG6PD_HUMAN
FullNameGlucose-6-phosphate 1-dehydrogenase
TaxID9606
Evidenceevidence at protein level
Length515
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesG6PD

GO terms

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GOName
GO:0004345 glucose-6-phosphate dehydrogenase activity
GO:0005536 glucose binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006098 pentose-phosphate shunt
GO:0006629 lipid metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0006739 NADP metabolic process
GO:0006740 NADPH regeneration
GO:0006749 glutathione metabolic process
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0009898 cytoplasmic side of plasma membrane
GO:0010041 response to iron(III) ion
GO:0010734 negative regulation of protein glutathionylation
GO:0014070 response to organic cyclic compound
GO:0016020 membrane
GO:0019322 pentose biosynthetic process
GO:0021762 substantia nigra development
GO:0032094 response to food
GO:0034451 centriolar satellite
GO:0034599 cellular response to oxidative stress
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043249 erythrocyte maturation
GO:0043523 regulation of neuron apoptotic process
GO:0045471 response to ethanol
GO:0046390 ribose phosphate biosynthetic process
GO:0050661 NADP binding
GO:0051156 glucose 6-phosphate metabolic process
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0070062 extracellular exosome
GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001282 Glucose-6-phosphate dehydrogenaseFamilyFamily
IPR019796 Glucose-6-phosphate dehydrogenase, active siteSiteActive site
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-bindingDomainDomain
IPR022675 Glucose-6-phosphate dehydrogenase, C-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03085 Glycolic acidDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB05107 16-BromoepiandrosteroneDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule