Entity Details

Primary name EF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13639
EntryNameEF2_HUMAN
FullNameElongation factor 2
TaxID9606
Evidenceevidence at protein level
Length858
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesEEF2

GO terms

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GOName
GO:0002039 p53 binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002931 response to ischemia
GO:0003009 skeletal muscle contraction
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006414 translational elongation
GO:0007568 aging
GO:0008097 5S rRNA binding
GO:0014009 glial cell proliferation
GO:0016020 membrane
GO:0016235 aggresome
GO:0019901 protein kinase binding
GO:0032355 response to estradiol
GO:0034774 secretory granule lumen
GO:0034976 response to endoplasmic reticulum stress
GO:0035914 skeletal muscle cell differentiation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042788 polysomal ribosome
GO:0043022 ribosome binding
GO:0043312 neutrophil degranulation
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045296 cadherin binding
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0051015 actin filament binding
GO:0051593 response to folic acid
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:1990904 ribonucleoprotein complex
GO:2000767 positive regulation of cytoplasmic translation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000640 Elongation factor EFG, domain V-likeDomainDomain
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR005225 Small GTP-binding protein domainDomainDomain
IPR005517 Translation elongation factor EFG/EF2, domain IVDomainDomain
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031157 Tr-type G domain, conserved siteSiteConserved site
IPR035647 EF-G domain III/V-likeFamilyHomologous superfamily
IPR041095 Elongation Factor G, domain IIDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02059 Adenosine-5-DiphosphoriboseDrugbanksmall molecule
DB03223 DiphthamideDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB12688 Moxetumomab PasudotoxDrugbankbiotech

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
EF2_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
EF2_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
EF2_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
EF2_HUMANEP300_HUMANBioGRID, MINT20808282 details
EF2_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
EF2_HUMANHSPB2_HUMANbhf-ucl26465331 details
EF2_HUMANEF2KT_HUMANBioGRID, IntAct23349634 25231979 26186194 28514442 details
EF2_HUMANHD_HUMANIntAct32814053 details
EF2_HUMANUCHL5_HUMANBioGRID21800051 details
EF2_HUMANEF2K_HUMANBioGRID, HPRD22669845 8386634 91085562 details
EF2_HUMANTCPB_HUMANBioGRID23190606 details
EF2_HUMANHNRPD_HUMANBioGRID15231747 details
EF2_HUMANARF_HUMANBioGRID17955473 details
EF2_HUMANESR1_HUMANBioGRID20348541 details
EF2_HUMANPTEN_HUMANBioGRID26561776 details
EF2_HUMANCPEB2_HUMANBioGRID22157746 details
EF2_HUMANSUMO2_HUMANBioGRID32786267 details
EF2_HUMANCBP_HUMANBioGRID32238831 details
EF2_HUMANRD23A_HUMANBioGRID, MINT16712842 details
EF2_HUMAN1433Z_HUMANMINT15161933 details
EF2_HUMANMAX_HUMANIntAct20195357 details
EF2_HUMANP53_HUMANBioGRID, HPRD, MINT12891704 22653443 32807901 details
EF2_HUMANAF9_HUMANBioGRID20431927 details
EF2_HUMANNOP56_HUMANBioGRID12777385 details
EF2_HUMANISG15_HUMANBioGRID16009940 33024031 details
EF2_HUMANHS90A_HUMANBioGRID16263121 details
EF2_HUMANITA4_HUMANBioGRID22623428 details
EF2_HUMANSEM1_HUMANBioGRID24515614 details
EF2_HUMANSEML_HUMANBioGRID24515614 details
EF2_HUMANSIR6_HUMANBioGRID24169447 details
EF2_HUMANGAN_HUMANBioGRID26460568 details
EF2_HUMANU2AF2_HUMANBioGRID26641092 details
EF2_HUMANZN598_HUMANBioGRID28685749 details
EF2_HUMANAKTIP_HUMANBioGRID27512140 details
EF2_HUMANCDC37_HUMANBioGRID16611982 details
EF2_HUMANSOX2_HUMANBioGRID21280222 details
EF2_HUMANPPIA_HUMANBioGRID25678563 details
EF2_HUMANBIN1_HUMANBioGRID31815296 details
EF2_HUMANCSPG4_HUMANBioGRID30131676 details
EF2_HUMANMAPK3_HUMANHPRD12171600 details
EF2_HUMANEF2_HUMANHPRD15835887 2318846 details
EF2_HUMANPP2AA_HUMANHPRD8386634 details
EF2_HUMANTRPM7_HUMANHPRD14594813 details
EF2_HUMANPPM1A_HUMANHPRD8386634 details