Entity Details

Primary name TYRO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14679
EntryNameTYRO_HUMAN
FullNameTyrosinase
TaxID9606
Evidenceevidence at protein level
Length529
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesTYR

GO terms

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GOName
GO:0004503 monophenol monooxygenase activity
GO:0005507 copper ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005798 Golgi-associated vesicle
GO:0005829 cytosol
GO:0006583 melanin biosynthetic process from tyrosine
GO:0006726 eye pigment biosynthetic process
GO:0007601 visual perception
GO:0008283 cell population proliferation
GO:0009411 response to UV
GO:0009637 response to blue light
GO:0016021 integral component of membrane
GO:0033162 melanosome membrane
GO:0033280 response to vitamin D
GO:0042438 melanin biosynthetic process
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043473 pigmentation
GO:0048471 perinuclear region of cytoplasm
GO:0048538 thymus development
GO:0051591 response to cAMP

Subcellular Location

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Subcellular Location
Melanosome
Melanosome membrane

Domains

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DomainNameCategoryType
IPR002227 Tyrosinase copper-binding domainDomainDomain
IPR008922 Uncharacterised domain, di-copper centreFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00548 Azelaic acidDrugbanksmall molecule
DB00600 MonobenzoneDrugbanksmall molecule
DB01055 MimosineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09526 HydroquinoneDrugbanksmall molecule
DB11217 ArbutinDrugbanksmall molecule
DB11254 HexylresorcinolDrugbanksmall molecule