Entity Details

Primary name VEGFA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15692
EntryNameVEGFA_HUMAN
FullNameVascular endothelial growth factor A
TaxID9606
Evidenceevidence at protein level
Length232
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesVEGFA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0002575 basophil chemotaxis
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003169 coronary vein morphogenesis
GO:0005125 cytokine activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005912 adherens junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010749 regulation of nitric oxide mediated signal transduction
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030141 secretory granule
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0031012 extracellular matrix
GO:0031077 post-embryonic camera-type eye development
GO:0031093 platelet alpha granule lumen
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035148 tube formation
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036303 lymph vessel morphogenesis
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0038191 neuropilin binding
GO:0042056 chemoattractant activity
GO:0042327 positive regulation of phosphorylation
GO:0042462 eye photoreceptor cell development
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048018 receptor ligand activity
GO:0048469 cell maturation
GO:0048593 camera-type eye morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 extracellular matrix binding
GO:0050918 positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060319 primitive erythrocyte differentiation
GO:0060749 mammary gland alveolus development
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0061042 vascular wound healing
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0071679 commissural neuron axon guidance
GO:0090037 positive regulation of protein kinase C signaling
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:0097475 motor neuron migration
GO:0097533 cellular stress response to acid chemical
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 positive regulation of p38MAPK cascade
GO:1901165 positive regulation of trophoblast cell migration
GO:1901727 positive regulation of histone deacetylase activity
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902966 positive regulation of protein localization to early endosome
GO:1903141 negative regulation of establishment of endothelial barrier
GO:1903392 negative regulation of adherens junction organization
GO:1903572 positive regulation of protein kinase D signaling
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905278 positive regulation of epithelial tube formation
GO:1905604 negative regulation of blood-brain barrier permeability
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000072 PDGF/VEGF domainDomainDomain
IPR023581 Platelet-derived growth factor, conserved siteSiteConserved site
IPR027928 Vascular endothelial growth factor, heparin-binding domainDomainDomain
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily
IPR036841 Vascular endothelial growth factor, heparin-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
603933 OMIMMicrovascular complications of diabetes 1 (MVCD1)Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00112 BevacizumabDrugbankbiotech
DB01017 MinocyclineDrugbanksmall molecule
DB01120 GliclazideDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01270 RanibizumabDrugbankbiotech
DB03088 Pidolic acidDrugbanksmall molecule
DB04895 PegaptanibDrugbankbiotech
DB05294 VandetanibDrugbanksmall molecule
DB05434 ABT-510Drugbanksmall molecule
DB05890 VeglinDrugbanksmall molecule
DB05932 DenibulinDrugbanksmall molecule
DB05969 SNS-032Drugbanksmall molecule
DB06642 BevasiranibDrugbankbiotech
DB06779 DalteparinDrugbanksmall molecule
DB08885 AfliberceptDrugbankbiotech
DB09301 Chondroitin sulfateDrugbanksmall molecule
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB14864 BrolucizumabDrugbankbiotech
DB15303 FaricimabDrugbankbiotech

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
VEGFA_HUMANVGFR2_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, matrixdb, MINT12716911 1417831 16423422 16763549 16901919 17318185 18325345 19818105 20145116 20660291 21596751 22897854 23374253 23583373 25644401 28303365 30236477 31932617 8621427 details
VEGFA_HUMANNRP1_HUMANBioGRID, HPRD, IntAct, MINT10409677 11886873 11986311 16423422 16763549 17222790 18325345 20363638 21939755 22318724 22897854 26804163 30236477 9529250 details
VEGFA_HUMANVGFR1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, matrixdb10543948 1312256 17051153 18593464 20660291 21596751 21939755 28514442 8621427 9393862 details
VEGFA_HUMANU2AF1_HUMANBioGRID, IntAct21988832 details
VEGFA_HUMANVPS35_HUMANBioGRID, IntAct21988832 details
VEGFA_HUMANTMG4_HUMANBioGRID, IntAct21988832 details
VEGFA_HUMANHIF1A_HUMANBioGRID, I2D, IntAct11901189 17413038 21602890 21620138 22952674 23549086 23928995 23991099 24434214 24656772 details
VEGFA_HUMANVEGFA_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT10748121 12086892 12207021 1312256 22897854 25132001 30236477 8631822 9207067 details
VEGFA_HUMANUBIA1_HUMANBioGRID, UniProt23169578 details
VEGFA_HUMANNGAL_HUMANIntAct32296183 details
VEGFA_HUMANCXB1_HUMANBioGRID, IntAct32296183 details
VEGFA_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
VEGFA_HUMANTM237_HUMANBioGRID, IntAct32296183 details
VEGFA_HUMANATS1_HUMANBioGRID, HPRD12716911 details
VEGFA_HUMANCCN2_HUMANBioGRID, HPRD11744618 details
VEGFA_HUMANIBP7_HUMANBioGRID, HPRD12407018 details
VEGFA_HUMANSPRC_HUMANBioGRID, HPRD25921830 9792673 details
VEGFA_HUMANVTNC_HUMANBioGRID, HPRD11796824 details
VEGFA_HUMANGPC1_HUMANBioGRID, HPRD10196157 details
VEGFA_HUMANCRYAB_HUMANBioGRID17487982 21984182 details
VEGFA_HUMANLYVE1_HUMANBioGRID7829517 details
VEGFA_HUMANU2AF5_HUMANBioGRID21988832 details
VEGFA_HUMANNRP2_HUMANBioGRID, HPRD10748121 17595163 details
VEGFA_HUMANFINC_HUMANBioGRID12114318 details
VEGFA_HUMANSP1_HUMANBioGRID15342781 details
VEGFA_HUMANSP3_HUMANBioGRID15342781 details
VEGFA_HUMANAP2A_HUMANBioGRID15342781 details
VEGFA_HUMANMOT8_HUMANBioGRID32296183 details
VEGFA_HUMANVEGFB_HUMANBioGRID, HPRD, IntAct25241761 26186194 28514442 8702615 details
VEGFA_HUMANPLGF_HUMANBioGRID, HPRD, IntAct12086892 12796773 25241761 details
VEGFA_HUMANSTAT3_HUMANBioGRID, IntAct23750211 23991099 details
VEGFA_HUMANTSP1_HUMANDIP19805200 details
VEGFA_HUMANHS90A_HUMANBioGRID18211808 details
VEGFA_HUMANHSP74_HUMANBioGRID18211808 23109422 details
VEGFA_HUMANHGS_HUMANBioGRID17445799 details
VEGFA_HUMANPTPRB_HUMANBioGRID25644401 details
VEGFA_HUMANPTPRZ_HUMANBioGRID25644401 details
VEGFA_HUMANCLUS_HUMANBioGRID26716898 details
VEGFA_HUMANUSF2_HUMANBioGRID23991099 details
VEGFA_HUMANFOS_HUMANBioGRID23549086 details
VEGFA_HUMANARNT_HUMANBioGRID17413038 25879517 details
VEGFA_HUMANSEM3F_HUMANHPRD12845630 details
VEGFA_HUMANTENX_HUMANHPRD11122379 details
VEGFA_HUMANEPHB2_HUMANHPRD17318185 details
VEGFA_HUMANAKT1_HUMANHPRD17318185 details
VEGFA_HUMANYBOX3_HUMANHPRD16198352 details
VEGFA_HUMANYBOX1_HUMANHPRD16198352 details