Entity Details

Primary name E2AK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19525
EntryNameE2AK2_HUMAN
FullNameInterferon-induced, double-stranded RNA-activated protein kinase
TaxID9606
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK2

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001819 positive regulation of cytokine production
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell population proliferation
GO:0009615 response to virus
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019888 protein phosphatase regulator activity
GO:0030683 mitigation of host immune response by virus
GO:0032722 positive regulation of chemokine production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033689 negative regulation of osteoblast proliferation
GO:0034198 cellular response to amino acid starvation
GO:0035455 response to interferon-alpha
GO:0042802 identical protein binding
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900225 regulation of NLRP3 inflammasome complex assembly
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901532 regulation of hematopoietic progenitor cell differentiation
GO:1902033 regulation of hematopoietic stem cell proliferation
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR044452 EIF2AK2, first double-stranded RNA binding domainDomainDomain
IPR044453 EIF2AK2, second double-stranded RNA binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618877 OMIMLeukoencephalopathy, developmental delay, and episodic neurologic regression syndrome (LEUDEN)An autosomal dominant disorder characterized by global developmental delay apparent in early childhood, cognitive impairment, ataxia, poor or absent speech with dysarthria, hypotonia, hypertonia, extrapyramidal signs, tremor, and abnormal involuntary movements. Affected individuals also exhibit neurological regression in the setting of febrile illness or infection. Many patients have seizures. Brain imaging shows diffuse white matter abnormalities with poor myelination. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
E2AK2_HUMANCDC42_HUMANBioGRID, HPRD, MINT31478661 7738010 details
E2AK2_HUMANNPM_HUMANBioGRID, HPRD, MINT12882984 16957780 details
E2AK2_HUMANIF2A_HUMANBioGRID, DIP, HPRD, IntAct, MINT10542257 11985496 12882984 16288713 1677563 17290288 18971339 19364808 21368187 8099444 9431994 9819435 details
E2AK2_HUMANCDK1_HUMANMINT20395957 details
E2AK2_HUMANDHX58_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANSPB1_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANMOV10_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANPRKRA_HUMANBioGRID, DIP, HPRD, IntAct11238927 11985496 16785445 21903422 23455922 24778252 32296183 9687506 details
E2AK2_HUMANIF6_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANSTAU2_HUMANBioGRID, IntAct21903422 24778252 details
E2AK2_HUMANTOLIP_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANDHX30_HUMANBioGRID, IntAct21903422 23455922 32877691 details
E2AK2_HUMANDICER_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANTRBP2_HUMANBioGRID, HPRD, IntAct10330179 11438532 21903422 7568151 details
E2AK2_HUMANEDC4_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANZN346_HUMANBioGRID, IntAct21903422 details
E2AK2_HUMANDHX9_HUMANBioGRID, IntAct19229320 21903422 details
E2AK2_HUMANRED1_HUMANBioGRID, IntAct32296183 details
E2AK2_HUMANE2AK2_HUMANBioGRID, DIP, HPRD10848580 11337501 11447118 12882984 16373505 18082144 29070839 7568151 8887659 9528799 details
E2AK2_HUMANNLRP3_HUMANDIP22801494 details
E2AK2_HUMANSTAT1_HUMANBioGRID, HPRD11278865 9135145 details
E2AK2_HUMANPP1A_HUMANBioGRID, HPRD12138106 details
E2AK2_HUMANP53_HUMANBioGRID, HPRD10348343 10747897 10884347 19631745 details
E2AK2_HUMANILF3_HUMANBioGRID, HPRD10320367 10400669 10684936 11438536 11438540 details
E2AK2_HUMANMAP2_HUMANBioGRID, HPRD11123929 details
E2AK2_HUMANDNJC3_HUMANBioGRID, HPRD8576172 9447982 details
E2AK2_HUMAN2A5A_HUMANBioGRID, HPRD10866685 details
E2AK2_HUMANILF2_HUMANBioGRID11438540 details
E2AK2_HUMANH2A2C_HUMANBioGRID9447982 details
E2AK2_HUMANTYK2_HUMANBioGRID, HPRD17290288 details
E2AK2_HUMANEIF2A_HUMANBioGRID19229320 29070839 details
E2AK2_HUMANH2A1B_HUMANBioGRID20484669 details
E2AK2_HUMANSUMO1_HUMANBioGRID29070839 details
E2AK2_HUMANUBC9_HUMANBioGRID29070839 details
E2AK2_HUMANOGT1_HUMANBioGRID32994395 details
E2AK2_HUMANXRN2_HUMANBioGRID, IntAct21903422 29395067 details
E2AK2_HUMANSTAU1_HUMANBioGRID, IntAct21903422 29395067 30948266 details
E2AK2_HUMANPP1G_HUMANBioGRID, HPRD, IntAct12138106 21903422 details
E2AK2_HUMANHS90B_HUMANIntAct22939624 details
E2AK2_HUMANAIM2_HUMANDIP22801494 details
E2AK2_HUMANNLRP1_HUMANDIP22801494 details
E2AK2_HUMANNLRC4_HUMANDIP22801494 details
E2AK2_HUMANG3BP2_HUMANIntAct33495715 details
E2AK2_HUMANFANCC_HUMANBioGRID12397061 15299030 details
E2AK2_HUMANPKRI1_HUMANBioGRID, HPRD12679338 details
E2AK2_HUMANM3K5_HUMANBioGRID, HPRD12473108 details
E2AK2_HUMANIKKA_HUMANBioGRID, HPRD10648614 10723127 10848580 details
E2AK2_HUMANIKKB_HUMANBioGRID, HPRD10848580 details
E2AK2_HUMANPGFRB_HUMANBioGRID, HPRD11350938 details
E2AK2_HUMANSTAT3_HUMANBioGRID, HPRD11350938 details
E2AK2_HUMANMAVS_HUMANBioGRID22022264 details
E2AK2_HUMANM3K7_HUMANBioGRID, HPRD12609980 details
E2AK2_HUMANISG15_HUMANBioGRID16009940 33024031 details
E2AK2_HUMANJAK1_HUMANBioGRID, HPRD17290288 details
E2AK2_HUMANHS90A_HUMANBioGRID, HPRD11447118 22939624 details
E2AK2_HUMANTEBP_HUMANBioGRID, HPRD11447118 details
E2AK2_HUMANTRAF5_HUMANBioGRID15121867 details
E2AK2_HUMANTRAF6_HUMANBioGRID15121867 25715336 details
E2AK2_HUMANTRAF2_HUMANBioGRID15121867 25715336 details
E2AK2_HUMANMACD1_HUMANBioGRID25735744 details
E2AK2_HUMANP52K_HUMANBioGRID, HPRD20484669 8576172 details
E2AK2_HUMANPTEN_HUMANBioGRID20029030 details
E2AK2_HUMANRL6_HUMANBioGRID12882984 details
E2AK2_HUMANRLA0_HUMANBioGRID12882984 details
E2AK2_HUMANRS2_HUMANBioGRID12882984 details
E2AK2_HUMANRS3A_HUMANBioGRID12882984 details
E2AK2_HUMANLMNA_HUMANBioGRID12882984 details
E2AK2_HUMANNHLC2_HUMANBioGRID30397336 31594818 details
E2AK2_HUMANSUMO2_HUMANBioGRID29070839 details
E2AK2_HUMANCASP3_HUMANHPRD11555640 details
E2AK2_HUMANCASP7_HUMANHPRD11555640 details
E2AK2_HUMANCASP8_HUMANHPRD11555640 details
E2AK2_HUMANRAC1_HUMANHPRD7738010 details
E2AK2_HUMANTIRAP_HUMANHPRD11526399 details
E2AK2_HUMANSTRBP_HUMANHPRD10684936 details
E2AK2_HUMANTAB2_HUMANHPRD12609980 details
E2AK2_HUMANELF2_HUMANHPRD17290288 details
E2AK2_HUMANHS71A_HUMANHPRD12397061 details
E2AK2_HUMANHS71B_HUMANHPRD12397061 details
E2AK2_HUMANIKBA_HUMANHPRD10723127 8601309 9214631 9721103 details