Entity Details

Primary name HME2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19622
EntryNameHME2_HUMAN
FullNameHomeobox protein engrailed-2
TaxID9606
Evidenceevidence at transcript level
Length333
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEN2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007275 multicellular organism development
GO:0016020 membrane
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048666 neuron development
GO:1990403 embryonic brain development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000747 Homeobox domain engrailedDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR019549 Homeobox engrailed, C-terminalDomainDomain
IPR019737 Homeobox engrailed-type, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03309 N-cyclohexyltaurineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HME2_HUMANFOXA2_HUMANBioGRID, HPRD12642491 details