Entity Details

Primary name XPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23025
EntryNameXPA_HUMAN
FullNameDNA repair protein complementing XP-A cells
TaxID9606
Evidenceevidence at protein level
Length273
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesXPA

GO terms

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GOName
GO:0000110 nucleotide-excision repair factor 1 complex
GO:0000715 nucleotide-excision repair, DNA damage recognition
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0003684 damaged DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009650 UV protection
GO:0010996 response to auditory stimulus
GO:0019904 protein domain specific binding
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034504 protein localization to nucleus
GO:0042803 protein homodimerization activity
GO:0045171 intercellular bridge
GO:0046872 metal ion binding
GO:0070911 global genome nucleotide-excision repair
GO:0070914 UV-damage excision repair
GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000465 XPAFamilyFamily
IPR009061 Putative DNA-binding domain superfamilyFamilyHomologous superfamily
IPR022652 Zinc finger, XPA-type, conserved siteSiteConserved site
IPR022656 XPA, C-terminalDomainDomain
IPR022658 XPA, conserved siteSiteConserved site
IPR037129 XPA domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
278700 OMIMXeroderma pigmentosum complementation group A (XP-A)An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-A patients show the most severe skin symptoms and progressive neurological disorders. The disease is caused by variants affecting the gene represented in this entry.

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
XPA_HUMANSYF1_HUMANBioGRID, HPRD, IntAct10944529 details
XPA_HUMANRASF1_HUMANHPRD, IntAct10888881 details
XPA_HUMANRFA2_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10982866 11081631 12527904 19996105 20304803 20670893 32296183 details
XPA_HUMANRFA1_HUMANBioGRID, DIP, HPRD, IntAct12527904 19446504 20304803 7565690 details
XPA_HUMANERCC1_HUMANBioGRID, DIP, HPRD, IntAct11058119 16491090 17948053 18597777 19056823 24036546 25416956 26186194 28514442 32296183 7598728 8197174 9013642 9653453 details
XPA_HUMANRPA34_HUMANIntAct11058119 details
XPA_HUMANGPN1_HUMANBioGRID, HPRD, IntAct11058119 details
XPA_HUMANSIR1_HUMANUniProt20670893 details
XPA_HUMANAURKA_HUMANBioGRID, MINT24412244 details
XPA_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
XPA_HUMANBUB1_HUMANBioGRID, MINT24412244 details
XPA_HUMANRHG07_HUMANBioGRID, MINT24412244 details
XPA_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
XPA_HUMANMLH1_HUMANBioGRID, MINT24412244 details
XPA_HUMANMLH3_HUMANBioGRID, MINT24412244 details
XPA_HUMANMUTYH_HUMANBioGRID, MINT24412244 details
XPA_HUMANRASN_HUMANBioGRID, MINT24412244 details
XPA_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
XPA_HUMANPMS2_HUMANBioGRID, MINT24412244 details
XPA_HUMANRB_HUMANBioGRID, MINT24412244 details
XPA_HUMANSMAD2_HUMANBioGRID, MINT24412244 details
XPA_HUMANSRC_HUMANBioGRID, MINT24412244 details
XPA_HUMANSTK11_HUMANBioGRID, MINT24412244 details
XPA_HUMANTRI27_HUMANBioGRID, IntAct25416956 32296183 details
XPA_HUMANNDEL1_HUMANBioGRID, IntAct25416956 32296183 details
XPA_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
XPA_HUMANDVL3_HUMANBioGRID, IntAct32296183 details
XPA_HUMANTBCD7_HUMANBioGRID, IntAct32296183 details
XPA_HUMANVP26C_HUMANBioGRID, IntAct32296183 details
XPA_HUMANRPAC1_HUMANBioGRID, IntAct32296183 details
XPA_HUMANPSB1_HUMANBioGRID, IntAct32296183 details
XPA_HUMANSNPH_HUMANBioGRID, IntAct32296183 details
XPA_HUMANZN655_HUMANBioGRID, IntAct32296183 details
XPA_HUMANSKIL_HUMANBioGRID, IntAct32296183 details
XPA_HUMANARI3A_HUMANBioGRID, IntAct32296183 details
XPA_HUMANXPF_HUMANBioGRID, IntAct26186194 28514442 9013642 details
XPA_HUMANHERC2_HUMANBioGRID, DIP20304803 23178497 details
XPA_HUMANPRKDC_HUMANBioGRID, DIP, HPRD16540648 20304803 details
XPA_HUMANRFA4_HUMANBioGRID, HPRD7565690 details
XPA_HUMANERPG3_HUMANBioGRID20541997 8999876 details
XPA_HUMANERCC6_HUMANBioGRID, HPRD20541997 8999876 details
XPA_HUMANT2EB_HUMANBioGRID, HPRD7876263 details
XPA_HUMANMSH2_HUMANBioGRID19468048 details
XPA_HUMANMSH3_HUMANBioGRID19468048 details
XPA_HUMANXPC_HUMANBioGRID12486030 17154534 details
XPA_HUMANDDB1_HUMANBioGRID19056823 details
XPA_HUMANDDB2_HUMANBioGRID, HPRD19056823 details
XPA_HUMANATM_HUMANBioGRID, HPRD16540648 details
XPA_HUMANATR_HUMANBioGRID, HPRD16540648 23178497 details
XPA_HUMANRHOU_HUMANBioGRID26598620 details
XPA_HUMANPCNA_HUMANBioGRID23152873 details
XPA_HUMANXPA_HUMANBioGRID23152873 31962067 details
XPA_HUMANMEOX2_HUMANBioGRID32296183 details
XPA_HUMANPRD16_HUMANBioGRID32296183 details
XPA_HUMANEP300_HUMANBioGRID11268218 details
XPA_HUMANTF2H1_HUMANBioGRID, HPRD11259578 9698541 details
XPA_HUMANRPB1_HUMANBioGRID16916636 details
XPA_HUMANHMGB1_HUMANBioGRID19446504 details
XPA_HUMANSPTA1_HUMANBioGRID16889989 details
XPA_HUMANERCC2_HUMANBioGRID18597777 details