Entity Details

Primary name ITA6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23229
EntryNameITA6_HUMAN
FullNameIntegrin alpha-6
TaxID9606
Evidenceevidence at protein level
Length1130
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesITGA6

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0007044 cell-substrate junction assembly
GO:0007229 integrin-mediated signaling pathway
GO:0009986 cell surface
GO:0010668 ectodermal cell differentiation
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0030175 filopodium
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030335 positive regulation of cell migration
GO:0031581 hemidesmosome assembly
GO:0031589 cell-substrate adhesion
GO:0031994 insulin-like growth factor I binding
GO:0034676 integrin alpha6-beta4 complex
GO:0035878 nail development
GO:0038132 neuregulin binding
GO:0042327 positive regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043236 laminin binding
GO:0043547 positive regulation of GTPase activity
GO:0043589 skin morphogenesis
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050900 leukocyte migration
GO:0071407 cellular response to organic cyclic compound
GO:0098609 cell-cell adhesion
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
226730 OMIMEpidermolysis bullosa letalis, with pyloric atresia (EB-PA)An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. The disease is caused by variants affecting the gene represented in this entry.