Entity Details

Primary name TYK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29597
EntryNameTYK2_HUMAN
FullNameNon-receptor tyrosine-protein kinase TYK2
TaxID9606
Evidenceevidence at protein level
Length1187
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesTYK2

GO terms

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GOName
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005131 growth hormone receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0031702 type 1 angiotensin receptor binding
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0070106 interleukin-27-mediated signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016045 Tyrosine-protein kinase, non-receptor, TYK2, N-terminalDomainDomain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
TYK2_HUMANINAR1_HUMANBioGRID, DIP, HPRD, MINT10523853 15337770 15356134 18474601 24704786 95059042 9677371 9733772 details
TYK2_HUMANUBE2F_HUMANIntAct19549727 details
TYK2_HUMANKHDR2_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
TYK2_HUMANDYN2_HUMANBioGRID, MINT21900206 details
TYK2_HUMANKITH_HUMANBioGRID, MINT21900206 details
TYK2_HUMANFHL3_HUMANBioGRID, IntAct21516116 25416956 32296183 details
TYK2_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
TYK2_HUMANHNRPK_HUMANBioGRID, IntAct25416956 29892012 32296183 details
TYK2_HUMANTRAF4_HUMANBioGRID, IntAct25416956 details
TYK2_HUMANKHDR3_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANAKP8L_HUMANIntAct32296183 details
TYK2_HUMANAGR2_HUMANIntAct32296183 details
TYK2_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANPRDM5_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANRACK1_HUMANBioGRID, HPRD12960323 details
TYK2_HUMANSTAT1_HUMANBioGRID, HPRD10918587 11294897 11839738 12637327 12817007 12960323 15322115 7543024 7657660 7690989 details
TYK2_HUMANANM5_HUMANBioGRID, HPRD10531356 details
TYK2_HUMANLYN_HUMANBioGRID, HPRD9633884 details
TYK2_HUMANPTN6_HUMANBioGRID, HPRD7629131 8780698 details
TYK2_HUMANFYN_HUMANBioGRID, HPRD9196040 details
TYK2_HUMANIRS2_HUMANBioGRID, HPRD8550573 details
TYK2_HUMANSOCS1_HUMANBioGRID21757742 29674694 29991678 details
TYK2_HUMANE2AK2_HUMANBioGRID, HPRD17290288 details
TYK2_HUMANCSN5_HUMANBioGRID24043623 details
TYK2_HUMANSIVA_HUMANBioGRID20727854 details
TYK2_HUMANASPP2_HUMANBioGRID32296183 details
TYK2_HUMANJKIP1_HUMANHPRD15277531 details
TYK2_HUMANKPCA_HUMANMINT17290288 details
TYK2_HUMANPTN1_HUMANBioGRID, HPRD, MINT11694501 details
TYK2_HUMANHS90B_HUMANIntAct22939624 details
TYK2_HUMANJAK2_HUMANIntAct26175413 details
TYK2_HUMANSTAT2_HUMANHPRD, IntAct32953130 8605877 details
TYK2_HUMANXRCC5_HUMANBioGRID, HPRD10673353 details
TYK2_HUMANVAV_HUMANBioGRID, HPRD10673353 details
TYK2_HUMANCRKL_HUMANBioGRID, HPRD9374471 details
TYK2_HUMANJAK1_HUMANBioGRID, HPRD7589562 8702790 details
TYK2_HUMANTYK2_HUMANBioGRID, HPRD7589562 details
TYK2_HUMANELP2_HUMANBioGRID10954736 details
TYK2_HUMANI13R1_HUMANBioGRID, HPRD10409622 details
TYK2_HUMANCBL_HUMANBioGRID, HPRD8780698 details
TYK2_HUMANUPAR_HUMANBioGRID, HPRD9417082 9974409 details
TYK2_HUMANIL6RB_HUMANBioGRID, HPRD9388212 details
TYK2_HUMANSTAM2_HUMANBioGRID, HPRD10899310 details
TYK2_HUMANGHR_HUMANBioGRID, HPRD10502458 details
TYK2_HUMANKLF10_HUMANBioGRID21471442 details
TYK2_HUMANLNX1_HUMANBioGRID22087225 details
TYK2_HUMANPTAFR_HUMANBioGRID, HPRD14500680 details
TYK2_HUMANHS90A_HUMANBioGRID22939624 details
TYK2_HUMANJAK3_HUMANBioGRID12207328 details
TYK2_HUMANSIAH2_HUMANBioGRID24833526 details
TYK2_HUMANUB2L6_HUMANBioGRID24833526 details
TYK2_HUMANPTN11_HUMANBioGRID9794795 details
TYK2_HUMANSOCS2_HUMANBioGRID28496097 details
TYK2_HUMANP85A_HUMANHPRD10995743 details
TYK2_HUMANINAR2_HUMANHPRD12960323 details
TYK2_HUMANPGFRB_HUMANHPRD8657151 9484840 details
TYK2_HUMANIRS1_HUMANHPRD8550573 details
TYK2_HUMANPTPRC_HUMANHPRD11201744 details