Entity Details

Primary name MMP16_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51512
EntryNameMMP16_HUMAN
FullNameMatrix metalloproteinase-16
TaxID9606
Evidenceevidence at protein level
Length607
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMMP16

GO terms

Show/Hide Table
GOName
GO:0001501 skeletal system development
GO:0001958 endochondral ossification
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0008047 enzyme activator activity
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0016485 protein processing
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0035988 chondrocyte proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0070006 metalloaminopeptidase activity
GO:0097094 craniofacial suture morphogenesis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell surface
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminalDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028697 Matrix metalloproteinase-16FamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB03880 BatimastatDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MMP16_HUMANLRP1_HUMANHPRD14645246 details
MMP16_HUMANKISS1_HUMANHPRD12879005 details