Entity Details

Primary name SYMC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56192
EntryNameSYMC_HUMAN
FullNameMethionine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length900
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
GO:0009267 cellular response to starvation
GO:0009303 rRNA transcription
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0032869 cellular response to insulin stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0070062 extracellular exosome
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR014758 Methionyl-tRNA synthetaseFamilyFamily
IPR015413 Methionyl/Leucyl tRNA synthetaseDomainDomain
IPR023458 Methionine-tRNA ligase, type 1FamilyFamily
IPR029038 Methionyl-tRNA synthetase, Zn-domainFamilyHomologous superfamily
IPR033911 Methioninyl-tRNA synthetase core domainDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041598 Methionine--tRNA ligase, N-terminalDomainDomain
IPR041872 Methionyl-tRNA synthetase, anticodon-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616280 OMIMCharcot-Marie-Tooth disease 2U (CMT2U)An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2U is a slowly progressive, autosomal dominant form characterized by late-adult onset. The disease is caused by variants affecting the gene represented in this entry.
615486 OMIMInterstitial lung and liver disease (ILLD)An autosomal recessive, life-threatening disorder characterized by respiratory insufficiency and progressive liver disease with onset in infancy or early childhood. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, pulmonary alveolar proteinosis, anemia, and liver canalicular cholestasis, steatosis, and iron deposition. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00134 MethionineDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
SYMC_HUMANHS90A_HUMANMINT10913161 details
SYMC_HUMANHNRL1_HUMANHPRD, IntAct16169070 details
SYMC_HUMANPPM1F_HUMANHPRD, IntAct16169070 details
SYMC_HUMANCSKP_HUMANBioGRID, IntAct21988832 details
SYMC_HUMANRS27_HUMANBioGRID, MINT21900206 details
SYMC_HUMANTNNT1_HUMANBioGRID, MINT21900206 details
SYMC_HUMANESR1_HUMANBioGRID, IntAct20348541 25604459 31527615 details
SYMC_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
SYMC_HUMANMCA3_HUMANBioGRID, DIP22863883 22939629 24212136 26344197 details
SYMC_HUMANSUMO2_HUMANBioGRID32786267 details
SYMC_HUMANNEMO_HUMANIntAct14743216 details
SYMC_HUMANM3K1_HUMANIntAct14743216 details
SYMC_HUMANM3K3_HUMANIntAct14743216 details
SYMC_HUMANNFKB2_HUMANIntAct14743216 details
SYMC_HUMANTF65_HUMANIntAct14743216 details
SYMC_HUMANWRP73_HUMANIntAct17353931 details
SYMC_HUMANTR10D_HUMANIntAct17353931 details
SYMC_HUMANMYC_HUMANBioGRID, IntAct17314511 17353931 29467282 details
SYMC_HUMANTFE3_HUMANIntAct17353931 details
SYMC_HUMANTRAF6_HUMANIntAct17353931 details
SYMC_HUMANHLAB_HUMANIntAct17353931 details
SYMC_HUMANMDM2_HUMANIntAct20195357 details
SYMC_HUMANHDAC5_HUMANBioGRID21081666 details
SYMC_HUMANCDK9_HUMANBioGRID20305087 27684187 details
SYMC_HUMANITA4_HUMANBioGRID22623428 details
SYMC_HUMANEGFR_HUMANBioGRID23956138 details
SYMC_HUMANLENG1_HUMANBioGRID26472760 details
SYMC_HUMANISG15_HUMANBioGRID33024031 details
SYMC_HUMANMAFK_HUMANHPRD9878398 details
SYMC_HUMANMK14_HUMANHPRD9878398 details