Entity Details

Primary name METK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00266
EntryNameMETK1_HUMAN
FullNameS-adenosylmethionine synthase isoform type-1
TaxID9606
Evidenceevidence at protein level
Length395
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesMAT1A

GO terms

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GOName
GO:0000096 sulfur amino acid metabolic process
GO:0001887 selenium compound metabolic process
GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009087 methionine catabolic process
GO:0032259 methylation
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051289 protein homotetramerization

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002133 S-adenosylmethionine synthetaseFamilyFamily
IPR022628 S-adenosylmethionine synthetase, N-terminalDomainDomain
IPR022629 S-adenosylmethionine synthetase, central domainDomainDomain
IPR022630 S-adenosylmethionine synthetase, C-terminalDomainDomain
IPR022631 S-adenosylmethionine synthetase, conserved siteSiteConserved site
IPR022636 S-adenosylmethionine synthetase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
250850 OMIMMethionine adenosyltransferase deficiency (MATD)An inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00118 AdemetionineDrugbanksmall molecule
DB00134 MethionineDrugbanksmall molecule
DB03191 3-Oxiran-2ylalanineDrugbanksmall molecule
DB03611 L-2-amino-4-methoxy-cis-but-3-enoic acidDrugbanksmall molecule

Interactions

4 interactions