Entity Details

Primary name MICA
Entity type gene
Source Source Link

Details

PrimaryID100507436
RefseqGeneNG_034139
SymbolMICA
NameMHC class I polypeptide-related sequence A
Chromosome6
Location6p21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2010-10-18
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsMICA_HUMAN

GO terms

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GOName
GO:0001913 T cell mediated cytotoxicity
GO:0002418 immune response to tumor cell
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006974 cellular response to DNA damage stimulus
GO:0009408 response to heat
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016032 viral process
GO:0019835 cytolysis
GO:0032815 negative regulation of natural killer cell activation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042742 defense response to bacterium
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0046629 gamma-delta T cell activation
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050776 regulation of immune response
GO:0051607 defense response to virus

Diseases

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Disease IDSourceNameDescription
177900 OMIMPsoriasis 1 (PSORS1)A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Disease susceptibility is associated with variants affecting the gene represented in this entry.
607507 OMIMPsoriatic arthritis (PSORAS)An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
MICAKLRC4-KLRK1IntAct, MINT11323699 21712812 details
MICAKLRK1HPRD, IntAct, MINT10426993 11323699 12902493 21712812 details
MICAPOT1bhf-ucl, BioGRID21044950 details
MICALGALS3MINT21712812 details
MICAKLRC4HPRD10426993 11323699 details
MICASCGB1D1BioGRID, IntAct28514442 details
MICATAFA3BioGRID, IntAct28514442 details
MICADEFA5BioGRID, IntAct28514442 details
MICAAVPBioGRID, IntAct28514442 details
MICASPINK4BioGRID, IntAct28514442 details
MICATAFAZZINBioGRID, IntAct26186194 28514442 details
MICATCTN1BioGRID, IntAct28514442 details
MICALYPD4BioGRID, IntAct28514442 details
MICAEPHA7BioGRID, IntAct28514442 details
MICAPTPRKBioGRID, IntAct26186194 28514442 details
MICAGGHBioGRID, IntAct26186194 28514442 details
MICAPGLYRP3BioGRID, IntAct26186194 28514442 details
MICAPHF7BioGRID, IntAct26186194 28514442 details
MICAAAR2BioGRID, IntAct26186194 28514442 details
MICAINSL5BioGRID, IntAct28514442 details
MICADEFA1BioGRID, IntAct28514442 details
MICADEFA1BIntAct28514442 details
MICAFLVCR1BioGRID, IntAct26186194 28514442 details
MICATNPO3BioGRID, IntAct26186194 28514442 details
MICAADAP2BioGRID, IntAct26186194 28514442 details
MICAERLEC1BioGRID, IntAct26186194 28514442 details
MICAVAMP3BioGRID, IntAct26186194 28514442 details
MICATNFSF9BioGRID, IntAct26186194 28514442 details
MICARYKBioGRID, IntAct26186194 28514442 details
MICASCAMP1BioGRID, IntAct26186194 28514442 details
MICATNFRSF10BBioGRID, IntAct26186194 28514442 details
MICAH2BC21BioGRID, IntAct30021884 details
MICAVAC14BioGRID26186194 details
MICATNPO2BioGRID26186194 28514442 details
MICANCR3LG1BioGRID26186194 details
MICAPGRMC2BioGRID26186194 details
MICAKIF14BioGRID31586073 details
MICATRIM25BioGRID29117863 details