Entity Details

Primary name FOXO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12778
EntryNameFOXO1_HUMAN
FullNameForkhead box protein O1
TaxID9606
Evidenceevidence at protein level
Length655
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesFOXO1

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001659 temperature homeostasis
GO:0001678 cellular glucose homeostasis
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008013 beta-catenin binding
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0032869 cellular response to insulin stimulus
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034599 cellular response to oxidative stress
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051721 protein phosphatase 2A binding
GO:0070166 enamel mineralization
GO:0070301 cellular response to hydrogen peroxide
GO:0070417 cellular response to cold
GO:0070542 response to fatty acid
GO:0071455 cellular response to hyperoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0097009 energy homeostasis
GO:1902617 response to fluoride
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:2000074 regulation of type B pancreatic cell development

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032067 FOXO protein, transactivation domainDomainDomain
IPR032068 FOXO protein, KIX-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
268220 OMIMRhabdomyosarcoma 2 (RMS2)A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving FOXO1 are found in rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3 and translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
FOXO1_HUMANESR1_HUMANBioGRID, HPRD, IntAct11353774 11435445 22266855 details
FOXO1_HUMANCDK1_HUMANIntAct18408765 details
FOXO1_HUMANANDR_HUMANBioGRID, HPRD, IntAct12482965 17202144 details
FOXO1_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT11237865 28205554 28514442 details
FOXO1_HUMANFHL2_HUMANBioGRID, HPRD, UniProt15692560 details
FOXO1_HUMANCBP_HUMANBioGRID, HPRD, MINT, UniProt10973497 15220471 16154098 24419059 25609649 details
FOXO1_HUMANAKT1_HUMANBioGRID, DIP, HPRD, IntAct10358014 10358075 16076959 18786403 25241761 31844113 details
FOXO1_HUMANSET_HUMANBioGRID, MINT24983498 27626385 details
FOXO1_HUMANEP300_HUMANBioGRID, MINT11896584 15890677 18786403 24419059 25609649 details
FOXO1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct11237865 28205554 28514442 details
FOXO1_HUMANSTK4_HUMANDIP18786403 details
FOXO1_HUMANETS1_HUMANIntAct24419615 details
FOXO1_HUMANTSC2_HUMANBioGRID17077083 details
FOXO1_HUMANCEBPB_HUMANBioGRID, HPRD11893744 details
FOXO1_HUMANHXA5_HUMANBioGRID, HPRD12163409 details
FOXO1_HUMANHNF4A_HUMANBioGRID, HPRD12519792 19740748 details
FOXO1_HUMANPARP1_HUMANBioGRID19281796 details
FOXO1_HUMANLPPRC_HUMANBioGRID17050673 details
FOXO1_HUMANSKP2_HUMANBioGRID15668399 19686743 28802579 30535125 details
FOXO1_HUMANSIR2_HUMANBioGRID15220471 20543840 24419059 details
FOXO1_HUMANMDM2_HUMANBioGRID19321440 27412556 details
FOXO1_HUMANRARA_HUMANBioGRID, HPRD11353774 details
FOXO1_HUMANHGFL_HUMANBioGRID18786403 details
FOXO1_HUMANNCOA1_HUMANBioGRID10973497 details
FOXO1_HUMANP55G_HUMANBioGRID25814554 details
FOXO1_HUMANTNS2_HUMANBioGRID25814554 details
FOXO1_HUMANKAPCA_HUMANBioGRID21177856 details
FOXO1_HUMANPITX1_HUMANBioGRID24065703 details
FOXO1_HUMANEHMT2_HUMANBioGRID30535125 details
FOXO1_HUMANDACH1_HUMANBioGRID28205554 details
FOXO1_HUMAN1433S_HUMANBioGRID28205554 details
FOXO1_HUMANNED4L_HUMANBioGRID31844113 details
FOXO1_HUMANCTNB1_HUMANHPRD15905404 details
FOXO1_HUMANPPARG_HUMANHPRD12966085 details
FOXO1_HUMANSIR1_HUMANBioGRID, DIP, HPRD, UniProt15220471 15692560 16154098 18235501 22013015 details
FOXO1_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct11980723 25241761 details
FOXO1_HUMANSMAD4_HUMANBioGRID, HPRD, IntAct15084259 details
FOXO1_HUMAN1433T_HUMANBioGRID, IntAct24419059 28514442 details
FOXO1_HUMAN1433B_HUMANBioGRID, IntAct16919273 28514442 details
FOXO1_HUMANSMAD3_HUMANBioGRID, HPRD15084259 details
FOXO1_HUMANCOP1_HUMANBioGRID18815134 details
FOXO1_HUMANHXA11_HUMANBioGRID19727442 details
FOXO1_HUMANPML_HUMANBioGRID16154098 details
FOXO1_HUMANATG7_HUMANBioGRID20543840 22622204 23640897 30689742 details
FOXO1_HUMANCHIP_HUMANBioGRID19483080 details
FOXO1_HUMANNLK_HUMANBioGRID20874444 details
FOXO1_HUMANFSHR_HUMANBioGRID17030088 details
FOXO1_HUMANIRF3_HUMANBioGRID23532851 details
FOXO1_HUMANCRY1_HUMANBioGRID27412556 28790135 details
FOXO1_HUMANSIR7_HUMANBioGRID28655758 details
FOXO1_HUMANATM_HUMANBioGRID27559048 details
FOXO1_HUMANMYH9_HUMANBioGRID31754475 details
FOXO1_HUMANSMAG2_HUMANBioGRID29395067 details
FOXO1_HUMANFOXG1_HUMANHPRD15084259 details
FOXO1_HUMANTHB_HUMANHPRD11353774 details
FOXO1_HUMANHXA10_HUMANHPRD12493691 details
FOXO1_HUMANSRC_HUMANHPRD10973497 details
FOXO1_HUMANG6PC1_HUMANHPRD11672436 details
FOXO1_HUMANPAK1_HUMANHPRD10358014 12560069 details
FOXO1_HUMANDYR1A_HUMANHPRD11311120 details