Entity Details

Primary name NFIA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12857
EntryNameNFIA_HUMAN
FullNameNuclear factor 1 A-type
TaxID9606
Evidenceevidence at protein level
Length509
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesNFIA

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0019079 viral genome replication
GO:0030054 cell junction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060074 synapse maturation
GO:0072189 ureter development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000647 CTF transcription factor/nuclear factor 1FamilyFamily
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR019548 CTF transcription factor/nuclear factor 1, N-terminalDomainDomain
IPR019739 CTF transcription factor/nuclear factor 1, conserved siteSiteConserved site
IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
613735 OMIMBrain malformations with or without urinary tract defects (BRMUTD)A syndrome characterized by corpus callosum hypoplasia or agenesis, hydrocephalus or ventricular enlargement, developmental delay, and urinary tract defects. The disease is caused by variants affecting the gene represented in this entry.