Entity Details

Primary name NLGN1
Entity type gene
Source Source Link

Details

PrimaryID22871
RefseqGeneNG_046919
SymbolNLGN1
Nameneuroligin 1
Chromosome3
Location3q26.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-02
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNLGN1_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006605 protein targeting
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007158 neuron cell-cell adhesion
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0014069 postsynaptic density
GO:0016080 synaptic vesicle targeting
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0017146 NMDA selective glutamate receptor complex
GO:0023041 neuronal signal transduction
GO:0030165 PDZ domain binding
GO:0030425 dendrite
GO:0031175 neuron projection development
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032433 filopodium tip
GO:0035418 protein localization to synapse
GO:0038023 signaling receptor activity
GO:0042043 neurexin family protein binding
GO:0042802 identical protein binding
GO:0043083 synaptic cleft
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043235 receptor complex
GO:0044877 protein-containing complex binding
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045664 regulation of neuron differentiation
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0048511 rhythmic process
GO:0048789 cytoskeletal matrix organization at active zone
GO:0050804 modulation of chemical synaptic transmission
GO:0050839 cell adhesion molecule binding
GO:0051491 positive regulation of filopodium assembly
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060076 excitatory synapse
GO:0060291 long-term synaptic potentiation
GO:0060999 positive regulation of dendritic spine development
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0071277 cellular response to calcium ion
GO:0072553 terminal button organization
GO:0089717 spanning component of membrane
GO:0097091 synaptic vesicle clustering
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097110 scaffold protein binding
GO:0097113 AMPA glutamate receptor clustering
GO:0097114 NMDA glutamate receptor clustering
GO:0097115 neurexin clustering involved in presynaptic membrane assembly
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:0098698 postsynaptic specialization assembly
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex
GO:0098985 asymmetric, glutamatergic, excitatory synapse
GO:0099054 presynapse assembly
GO:0099055 integral component of postsynaptic membrane
GO:0099060 integral component of postsynaptic specialization membrane
GO:0099560 synaptic membrane adhesion
GO:0140058 neuron projection arborization
GO:1900029 positive regulation of ruffle assembly
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:1902474 positive regulation of protein localization to synapse
GO:1902533 positive regulation of intracellular signal transduction
GO:1904861 excitatory synapse assembly
GO:1905520 positive regulation of presynaptic active zone assembly
GO:2000302 positive regulation of synaptic vesicle exocytosis
GO:2000310 regulation of NMDA receptor activity
GO:2000311 regulation of AMPA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000809 positive regulation of synaptic vesicle clustering

Diseases

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Disease IDSourceNameDescription
618830 OMIMAutism 20 (AUTS20)A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. The transmission pattern of AUTS20 is consistent with autosomal dominant inheritance. Disease susceptibility is associated with variants affecting the gene represented in this entry.