Entity Details

Primary name GCLM
Entity type gene
Source Source Link

Details

PrimaryID2730
RefseqGeneNG_012072
SymbolGCLM
Nameglutamate-cysteine ligase modifier subunit
Chromosome1
Location1p22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-11-08
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGSH0_HUMAN

GO terms

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GOName
GO:0004357 glutamate-cysteine ligase activity
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0006536 glutamate metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008637 apoptotic mitochondrial changes
GO:0014823 response to activity
GO:0017109 glutamate-cysteine ligase complex
GO:0030234 enzyme regulator activity
GO:0035226 glutamate-cysteine ligase catalytic subunit binding
GO:0035229 positive regulation of glutamate-cysteine ligase activity
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035733 hepatic stellate cell activation
GO:0042493 response to drug
GO:0043524 negative regulation of neuron apoptotic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044752 response to human chorionic gonadotropin
GO:0044877 protein-containing complex binding
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0051409 response to nitrosative stress
GO:0051900 regulation of mitochondrial depolarization
GO:0071333 cellular response to glucose stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0097069 cellular response to thyroxine stimulus
GO:0097746 blood vessel diameter maintenance
GO:1990830 cellular response to leukemia inhibitory factor
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
GCLMCALM1BioGRID, IntAct21988832 details
GCLMCALM2IntAct21988832 details
GCLMCALM3IntAct21988832 details
GCLMIRF7BioGRID, IntAct21988832 details
GCLMSTOX1BioGRID, IntAct21988832 details
GCLMOSGIN1BioGRID, IntAct32296183 details
GCLMGCLCBioGRID, IntAct26344197 28514442 9675072 9841880 details
GCLMPHLDA3IntAct17353931 details
GCLMCBWD1IntAct17353931 details
GCLMFTSJ1IntAct17353931 details
GCLMARF6IntAct17353931 details
GCLMMCCIntAct17353931 details
GCLMTNFRSF14IntAct17353931 details
GCLMCUL3BioGRID, IntAct21145461 details
GCLMOTUB1BioGRID, IntAct26752685 details
GCLMHSCBBioGRID, IntAct28380382 details
GCLMDNA2BioGRID, IntAct28514442 details
GCLMPLAURBioGRID, IntAct26186194 28514442 details
GCLMPRKCABioGRID, IntAct28514442 details
GCLMTRPV5BioGRID, IntAct26186194 28514442 details
GCLMPARP12BioGRID, IntAct28514442 details
GCLMUROSBioGRID, IntAct26186194 28514442 details
GCLMRRP1BIntAct20926688 details
GCLMLRRK2IntAct31046837 details
GCLMSORDBioGRID22939629 details
GCLMGLRX3BioGRID22863883 details
GCLMGNAI2BioGRID22863883 details
GCLMNAGKBioGRID22863883 details
GCLMEGFRBioGRID24797263 details
GCLMCPNE3BioGRID26344197 details
GCLMTRIM14BioGRID29053956 details
GCLMEGLN3BioGRID26972000 details
GCLMEFTUD2BioGRID28515276 details
GCLMAAR2BioGRID28515276 details
GCLMPIH1D1BioGRID28515276 details
GCLMNR2C2BioGRID30463901 details
GCLMRPS6KA1BioGRID31678930 details
GCLMNINBioGRID28718761 details
GCLMPLEKHA4BioGRID31091453 details
GCLMIMMP2LBioGRID31617661 details