Entity Details

Primary name HYAL1
Entity type gene
Source Source Link

Details

PrimaryID3373
RefseqGeneNG_009295
SymbolHYAL1
Namehyaluronidase 1
Chromosome3
Location3p21.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-06-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsHYAL1_HUMAN

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0004415 hyalurononglucosaminidase activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005975 carbohydrate metabolic process
GO:0006954 inflammatory response
GO:0008134 transcription factor binding
GO:0009615 response to virus
GO:0010634 positive regulation of epithelial cell migration
GO:0030207 chondroitin sulfate catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030213 hyaluronan biosynthetic process
GO:0030214 hyaluronan catabolic process
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0031410 cytoplasmic vesicle
GO:0036117 hyaluranon cable
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0043202 lysosomal lumen
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045927 positive regulation of growth
GO:0046677 response to antibiotic
GO:0046718 viral entry into host cell
GO:0050501 hyaluronan synthase activity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051216 cartilage development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0070062 extracellular exosome
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071467 cellular response to pH
GO:0071493 cellular response to UV-B
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900106 positive regulation of hyaluranon cable assembly

Diseases

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Disease IDSourceNameDescription
601492 OMIMMucopolysaccharidosis 9 (MPS9)A lysosomal storage disease characterized by high hyaluronan concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. The disease is caused by variants affecting the gene represented in this entry.

Interactions

7 interactions

InteractorPartnerSourcesPublicationsLink
HYAL1COL2A1BioGRID, IntAct21988832 details
HYAL1UBAC1BioGRID, IntAct28514442 details
HYAL1UBR2BioGRID, IntAct28514442 details
HYAL1RNF123BioGRID, IntAct28514442 details
HYAL1UBR4BioGRID, IntAct28514442 details
HYAL1TUBA4ABioGRID, IntAct28514442 details
HYAL1TUBA1BBioGRID, IntAct28514442 details