Entity Details

Primary name KPCD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15139
EntryNameKPCD1_HUMAN
FullNameSerine/threonine-protein kinase D1
TaxID9606
Evidenceevidence at protein level
Length912
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPRKD1

GO terms

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GOName
GO:0000421 autophagosome membrane
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0010508 positive regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0010837 regulation of keratinocyte proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0030154 cell differentiation
GO:0031647 regulation of protein stability
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034198 cellular response to amino acid starvation
GO:0034599 cellular response to oxidative stress
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045806 negative regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048193 Golgi vesicle transport
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060548 negative regulation of cell death
GO:0071447 cellular response to hydroperoxide
GO:0089700 protein kinase D signaling
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901727 positive regulation of histone deacetylase activity
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001044 regulation of integrin-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015727 Protein kinase C mu-relatedFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain

Diseases

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Disease IDSourceNameDescription
617364 OMIMCongenital heart defects and ectodermal dysplasia (CHDED)An autosomal dominant syndrome characterized by atrial and/or ventricular septal congenital heart defects and variable features of ectodermal dysplasia, including sparse hair, dry skin, thin skin, fragile nails, premature loss of primary teeth, and small widely spaced teeth. Patients manifest developmental disabilities ranging from motor delay and delayed speech to global developmental retardation. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11752 Bryostatin 1Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
KPCD1_HUMANMT2_HUMANBioGRID, HPRD, IntAct14550308 details
KPCD1_HUMANCADH1_HUMANIntAct15695390 details
KPCD1_HUMANMK13_HUMANIntAct19135240 details
KPCD1_HUMANC1QBP_HUMANBioGRID, HPRD, UniProt10831594 details
KPCD1_HUMANKPCD1_HUMANBioGRID, HPRD, UniProt10831594 10867018 11741879 12628923 31980649 details
KPCD1_HUMANMARK2_HUMANDIP19011111 details
KPCD1_HUMANKPCE_HUMANDIP, HPRD10092595 19011111 details
KPCD1_HUMAN1433T_HUMANBioGRID, HPRD, IntAct10092600 10831594 31980649 details
KPCD1_HUMAN1433Z_HUMANBioGRID, IntAct12893243 31980649 details
KPCD1_HUMANHSPB1_HUMANBioGRID, IntAct15728188 31980649 details
KPCD1_HUMANARFP1_HUMANIntAct22981988 details
KPCD1_HUMANADAP1_HUMANBioGRID, HPRD12893243 details
KPCD1_HUMANBTK_HUMANBioGRID, HPRD10561498 details
KPCD1_HUMANJUN_HUMANBioGRID, HPRD11948398 12628923 details
KPCD1_HUMANCSN7A_HUMANBioGRID12628923 details
KPCD1_HUMANCSN2_HUMANBioGRID12628923 details
KPCD1_HUMANCSN5_HUMANBioGRID12628923 details
KPCD1_HUMANP53_HUMANBioGRID12628923 details
KPCD1_HUMANIBTK_HUMANBioGRID21482705 details
KPCD1_HUMANAKP13_HUMANBioGRID15383279 details
KPCD1_HUMANPP14A_HUMANBioGRID, HPRD15003508 details
KPCD1_HUMANAP2A_HUMANBioGRID18845787 details
KPCD1_HUMANNOS1_HUMANBioGRID24740233 details
KPCD1_HUMANUBP28_HUMANBioGRID24623306 details
KPCD1_HUMANSPY2_HUMANBioGRID19458088 details
KPCD1_HUMANHS90B_HUMANIntAct22939624 details
KPCD1_HUMANNHRF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KPCD1_HUMANYAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
KPCD1_HUMANHDAC5_HUMANBioGRID, HPRD11081517 11114197 15367659 15728188 21081666 26137861 details
KPCD1_HUMANMK09_HUMANBioGRID, HPRD11948398 details
KPCD1_HUMANMK08_HUMANBioGRID, HPRD11948398 details
KPCD1_HUMANPLCG1_HUMANBioGRID, HPRD8885868 details
KPCD1_HUMANKSYK_HUMANBioGRID, HPRD8885868 details
KPCD1_HUMANPLCG2_HUMANBioGRID, HPRD8885868 details
KPCD1_HUMANHDAC7_HUMANBioGRID, HPRD15623513 15738054 19029091 details
KPCD1_HUMANBAD_HUMANBioGRID20179209 details
KPCD1_HUMANGAN_HUMANBioGRID26460568 details
KPCD1_HUMANSNAI1_HUMANBioGRID28892081 details
KPCD1_HUMANFBW1A_HUMANBioGRID30619291 details
KPCD1_HUMANSRC_HUMANHPRD12637538 details
KPCD1_HUMANKPCL_HUMANHPRD10867018 11741879 details
KPCD1_HUMANKDIS_HUMANHPRD10998417 details
KPCD1_HUMANRACK1_HUMANHPRD11884618 details
KPCD1_HUMANIGF1R_HUMANHPRD11884618 details
KPCD1_HUMANEGFR_HUMANHPRD10523301 2984676 2987962 details
KPCD1_HUMANABL1_HUMANHPRD12637538 details
KPCD1_HUMANEPAS1_HUMANHPRD17024177 details