Entity Details

Primary name DUOX2
Entity type gene
Source Source Link

Details

PrimaryID50506
RefseqGeneNG_009447
SymbolDUOX2
Namedual oxidase 2
Chromosome15
Location15q21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-05-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDUOX2_HUMAN

GO terms

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GOName
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006590 thyroid hormone generation
GO:0006952 defense response
GO:0006979 response to oxidative stress
GO:0009615 response to virus
GO:0009986 cell surface
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016324 apical plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0020037 heme binding
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0042335 cuticle development
GO:0042446 hormone biosynthetic process
GO:0042554 superoxide anion generation
GO:0042744 hydrogen peroxide catabolic process
GO:0043020 NADPH oxidase complex
GO:0045177 apical part of cell
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051591 response to cAMP
GO:0070062 extracellular exosome
GO:0090303 positive regulation of wound healing
GO:0106293 NADH oxidase H202-forming activity
GO:0106294 NADPH oxidase H202-forming activity
GO:2000147 positive regulation of cell motility

Diseases

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Disease IDSourceNameDescription
607200 OMIMThyroid dyshormonogenesis 6 (TDH6)A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
DUOX2TXNDC11HPRD, UniProt15561711 details
DUOX2DUOXA2UniProt25761904 details
DUOX2BIRC3BioGRID30948266 details
DUOX2CITBioGRID31586073 details
DUOX2INSBioGRID32457219 details
DUOX2STAT1IntAct21321110 details