Entity Details

Primary name FCRL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96P31
EntryNameFCRL3_HUMAN
FullNameFc receptor-like protein 3
TaxID9606
Evidenceevidence at protein level
Length734
SequenceStatuscomplete
DateCreated2008-04-29
DateModified2021-06-02

Ontological Relatives

GenesFCRL3

GO terms

Show/Hide Table
GOName
GO:0002638 negative regulation of immunoglobulin production
GO:0004888 transmembrane signaling receptor activity
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0009986 cell surface
GO:0019900 kinase binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030890 positive regulation of B cell proliferation
GO:0034163 regulation of toll-like receptor 9 signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045577 regulation of B cell differentiation
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0050864 regulation of B cell activation
GO:0090279 regulation of calcium ion import
GO:1905184 positive regulation of protein serine/threonine phosphatase activity
GO:1990782 protein tyrosine kinase binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
180300 OMIMRheumatoid arthritis (RA)An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Disease susceptibility is associated with variants affecting the gene represented in this entry.