Entity Details

Primary name ACSL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60488
EntryNameACSL4_HUMAN
FullNameLong-chain-fatty-acid--CoA ligase 4
TaxID9606
Evidenceevidence at protein level
Length711
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesACSL4

GO terms

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GOName
GO:0001676 long-chain fatty acid metabolic process
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0007584 response to nutrient
GO:0008610 lipid biosynthetic process
GO:0015908 fatty acid transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019432 triglyceride biosynthetic process
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0031957 very long-chain fatty acid-CoA ligase activity
GO:0032024 positive regulation of insulin secretion
GO:0032307 negative regulation of prostaglandin secretion
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0043025 neuronal cell body
GO:0044233 mitochondria-associated endoplasmic reticulum membrane
GO:0047676 arachidonate-CoA ligase activity
GO:0060136 embryonic process involved in female pregnancy
GO:0060996 dendritic spine development
GO:0070062 extracellular exosome
GO:0070672 response to interleukin-15

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion outer membrane
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR000873 AMP-dependent synthetase/ligaseDomainDomain
IPR020845 AMP-binding, conserved siteSiteConserved site
IPR042099 ANL, N-terminal domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300387 OMIMMental retardation, X-linked 63 (MRX63)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.
300194 OMIMAlport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR)An X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, sensorineural hearing loss, mental retardation, midface hypoplasia and elliptocytosis. The gene represented in this entry may be involved in disease pathogenesis.

Drugs

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DrugNameSourceType
DB00159 IcosapentDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule